Rawal's catalyst as an effective stimulant for the highly asymmetric Michael addition of β-keto esters to functionally rich nitro-olefins

A. Suresh Kumar, T. Prabhakar Reddy, R. Madhavachary, Dhevalapally B. Ramachary*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)

Abstract

A general approach to asymmetric synthesis of highly substituted dihydroquinolines was achieved through neighboring ortho-amino group engaged sequential Michael/amination/dehydration reactions on (E)-2-(2-nitrovinyl)anilines with cyclic and acyclic β-keto esters in the presence of a catalytic amount of Rawal's quinidine-NH-benzyl squaramide followed by TFA.

Original languageEnglish
Pages (from-to)5494-5499
Number of pages6
JournalOrganic and Biomolecular Chemistry
Volume14
Issue number24
Early online date13 Nov 2015
DOIs
Publication statusE-pub ahead of print - 13 Nov 2015

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