RE coil: an antimicrobial peptide regulator

MG Ryadnov; GV Mukamolova; AS Hawrani; J Spencer; R Platt

doi:10.1002/anie.200904780

RE coil: an antimicrobial peptide regulator

MG Ryadnov, GV Mukamolova, AS Hawrani, J Spencer, R Platt

Research output: Contribution to journal › Article (Academic Journal) › peer-review

14 Citations (Scopus)

Abstract

Peptides that make bacteria RE coil: A peptide system designed to regulate antimicrobial intervention switches between antimicrobial and inactive forms. The regulator comprises two α-helical sequences. One of them, R coil, binds to microbial membranes and acts as an antimicrobial component, and is inactivated by the other, E coil, a membrane-inactive peptide (see picture).

Translated title of the contribution	RE coil: an antimicrobial peptide regulator
Original language	English
Pages (from-to)	9676 - 9679
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	51
DOIs	https://doi.org/10.1002/anie.200904780
Publication status	Published - 14 Dec 2009

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abstract = "Peptides that make bacteria RE coil: A peptide system designed to regulate antimicrobial intervention switches between antimicrobial and inactive forms. The regulator comprises two α-helical sequences. One of them, R coil, binds to microbial membranes and acts as an antimicrobial component, and is inactivated by the other, E coil, a membrane-inactive peptide (see picture).",

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year = "2009",

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T1 - RE coil: an antimicrobial peptide regulator

AU - Ryadnov, MG

AU - Mukamolova, GV

AU - Hawrani, AS

AU - Spencer, J

AU - Platt, R

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Y1 - 2009/12/14

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AB - Peptides that make bacteria RE coil: A peptide system designed to regulate antimicrobial intervention switches between antimicrobial and inactive forms. The regulator comprises two α-helical sequences. One of them, R coil, binds to microbial membranes and acts as an antimicrobial component, and is inactivated by the other, E coil, a membrane-inactive peptide (see picture).

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U2 - 10.1002/anie.200904780

DO - 10.1002/anie.200904780

M3 - Article (Academic Journal)

C2 - 19937880

SN - 1433-7851

VL - 48

SP - 9676

EP - 9679

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 51

ER -

RE coil: an antimicrobial peptide regulator

Abstract

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