TY - JOUR
T1 - Re-programming immunosurveillance in persistent non-infectious ocular inflammation
AU - Epps, Simon J.
AU - Boldison, Joanne
AU - Stimpson, Madeleine L.
AU - Khera, Tarnjit K.
AU - Lait, Philippa J.P.
AU - Copland, David A.
AU - Dick, Andrew D.
AU - Nicholson, Lindsay B.
PY - 2018/7/1
Y1 - 2018/7/1
N2 - Ocular function depends on a high level of anatomical integrity. This is threatened by inflammation, which alters the local tissue over short and long time-scales. Uveitis due to autoimmune disease, especially when it involves the retina, leads to persistent changes in how the eye interacts with the immune system. The normal pattern of immune surveillance, which for immune privileged tissues is limited, is re-programmed. Many cell types, that are not usually present in the eye, become detectable. There are changes in the tissue homeostasis and integrity. In both human disease and mouse models, in the most extreme cases, immunopathological findings consistent with development of ectopic lymphoid-like structures and disrupted angiogenesis accompany severely impaired eye function. Understanding how the ocular environment is shaped by persistent inflammation is crucial to developing novel approaches to treatment.
AB - Ocular function depends on a high level of anatomical integrity. This is threatened by inflammation, which alters the local tissue over short and long time-scales. Uveitis due to autoimmune disease, especially when it involves the retina, leads to persistent changes in how the eye interacts with the immune system. The normal pattern of immune surveillance, which for immune privileged tissues is limited, is re-programmed. Many cell types, that are not usually present in the eye, become detectable. There are changes in the tissue homeostasis and integrity. In both human disease and mouse models, in the most extreme cases, immunopathological findings consistent with development of ectopic lymphoid-like structures and disrupted angiogenesis accompany severely impaired eye function. Understanding how the ocular environment is shaped by persistent inflammation is crucial to developing novel approaches to treatment.
KW - Angiogenesis
KW - EAU
KW - Ectopic lymphoid tissue
KW - Immunosurveillance
KW - Uveitis
UR - http://www.scopus.com/inward/record.url?scp=85043981947&partnerID=8YFLogxK
U2 - 10.1016/j.preteyeres.2018.03.001
DO - 10.1016/j.preteyeres.2018.03.001
M3 - Review article (Academic Journal)
C2 - 29530739
AN - SCOPUS:85043981947
SN - 1350-9462
VL - 65
SP - 93
EP - 106
JO - Progress in Retinal and Eye Research
JF - Progress in Retinal and Eye Research
ER -