Reassuring fetal middle cerebral artery Doppler velocimetry in alloirnmunised pregnancies: Neonatal outcomes without invasive procedures

SA Abdel-Fattah*, J Shefras, PM Kyle, P Cairns, A Hunter, PW Soothill

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

Objective: To assess the neonatal outcome in red blood cell alloimmunised pregnancies at increased risk of fetal anaemia where invasive testing was avoided based on reassuring middle cerebral artery (MCA) Doppler velocity results. Methods: We included 28 alloimmunised pregnant women at significant risk of fetal or neonatal anaemia who did not have invasive testing because of reassuring MCA Doppler velocimetry. Women requiring invasive testing or intrauterine transfusion were excluded. Outcome measures were admission to neonatal intensive care unit, cord haemoglobin and bilirubin levels and neonatal therapy. Results: Ten neonates (36%) were anaemic at birth while 18 (64%) had normal haemoglobin. Seven neonates (25%) did not require any form of neonatal therapy, 10 (36%) had phototherapy only, 7 (25%) required exchange transfusions and 4 (14%) top-up transfusions. There were no treatment-related complications. Mean cord haemoglobin was 13.9 g/dl (range 7-18.9) and mean bilirubin was 84.1 4mol/l (range 29-192). Conclusion: Avoiding invasive procedures in pregnancies at risk of fetal anaemia by relying on reassuring MCA Doppler velocimetry did not result in life-threatening fetal or neonatal morbidities. The extent of neonatal therapy was acceptable. The routine use of this test can lead to less unnecessary invasive procedures in at-risk fetuses. Copyright (c) 2005 S. Karger AG, Basel.

Original languageEnglish
Pages (from-to)341-345
Number of pages5
JournalFetal Diagnosis and Therapy
Volume20
Issue number5
Publication statusPublished - 2005

Keywords

  • fetal anaemia
  • middle cerebral artery Doppler
  • red cell alloimmunisation
  • RED-CELL ALLOIMMUNIZATION
  • PEAK SYSTOLIC VELOCITY
  • NONINVASIVE DIAGNOSIS
  • GESTATIONAL-AGE
  • ANEMIA
  • PREDICTION
  • ULTRASONOGRAPHY
  • ISOIMMUNIZATION
  • TRANSFUSIONS
  • ULTRASOUND

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