Recent Advances in Organocatalytic Glycosylations

Ryan Williams, Carmen Galan*

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

41 Citations (Scopus)
329 Downloads (Pure)

Abstract

Carbohydrates play a pivotal role in biological systems and present an opportunity to develop potent carbohydrate-derived therapeutics and diagnostic tools for the treatment and detection of disease. To better comprehend the biological functions of carbohydrates, access to pure and structurally defined oligosaccharides is needed. Oligosaccharides are commonly synthesized by chemical means; however, despite progress in glycosylation chemistry, the efficient and stereoselective formation of glycosidic bonds by mild, nontoxic and low-cost methods remains a challenge. Organocatalysis is an exciting field that utilizes small organic molecules to effect chemical transformation where traditionally transition metal catalysis would be required. This microreview presents recent advances in the application of organocatalysis to carbohydrate chemistry and in particular to the stereoselective synthesis of oligosaccharides.

Original languageEnglish
Pages (from-to)6247-6264
Number of pages18
JournalEuropean Journal of Organic Chemistry
Volume2017
Issue number42
Early online date8 Sep 2017
DOIs
Publication statusPublished - 16 Nov 2017

Keywords

  • Glycosylation
  • Organocatalysis
  • Oligosaccharides
  • Stereoselectivity
  • Homogeneous catalysis

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