Recent advances in retromer biology

IJ McGough, PJ Cullen

Research output: Contribution to journalArticle (Academic Journal)peer-review

94 Citations (Scopus)


The endosomal network is an organized array of intracellular, membranous compartments that function as sorting sites for endosomal and biosynthetic cargo. The fate of endocytic cargo is reliant upon interactions with a number of molecularly distinct sorting complexes, which tightly control the relationship between sorting of their respective cargo and the physical process of membrane re-scuplturing required for the formation of transport carries. One such complex, retromer, mediates retrograde transport from endosomes to the trans-Golgi network (TGN). Disregulation of retromer has been implicated in a host of disease states including late-onset Alzheimer's. Rather than give a broad overview of retromer biology, here we aim to outline the recent advances in understanding this complex, focussing on the involvement of both clathrin and the cytoskeleton in retromer function.
Translated title of the contributionRecent advances in retromer biology
Original languageEnglish
Pages (from-to)963 - 971
Number of pages9
Volume12 (8)
Publication statusPublished - Aug 2011


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