Reconstruction of the swine pulmonary artery using a graft engineered with syngeneic cardiac pericytes

Valeria V Alvino, Anita C Thomas, Mohamed Ghorbel, Filippo Rapetto, Srinivas Narayan, Michael Kilcooley, Dominga Iacobazzi, Michele Carrabba, Marco Fagnano, William R Cathery, Elisa Avolio, Massimo Caputo*, Paolo R Madeddu*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

5 Citations (Scopus)
107 Downloads (Pure)
Original languageEnglish
Article number715717
Number of pages15
JournalFrontiers in Bioengineering and Biotechnology
Publication statusPublished - 9 Sept 2021

Bibliographical note

Funding Information:
Hannah Martin, Laboratory Assistant at the University of Bristol is acknowledged for technical assistance.

Funding Information:
This study was supported by the grants from the Sir Jules Thorn Charitable Trust (MCap, and PM), the Enid Linder Foundation (MCap and MRG), the British Heart Foundation (PM), the National Institute for Health Research (NIHR) Bristol Biomedical Research Centre in Cardiovascular Medicine (MCap, PM), and the Medical Research Council with the grant number MR/N027086/1 and entitled “In vitro and in vivo preclinical testing of pericyte-engineered grafts for correction of congenital heart defects” (PM, MCap, and MG).

Publisher Copyright:
© Copyright © 2021 Alvino, Thomas, Ghorbel, Rapetto, Narayan, Kilcooley, Iacobazzi, Carrabba, Fagnano, Cathery, Avolio, Caputo and Madeddu.


  • pericytes
  • grafts
  • congenital heart disease
  • pulmonary artery
  • tissue engineering

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