Redefining the cerebellar cortex as an assembly of non-uniform Purkinje cell microcircuits

Nadia L. Cerminara, Eric J. Lang, Roy V. Sillitoe, Richard Apps*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

101 Citations (Scopus)

Abstract

The adult mammalian cerebellar cortex is generally assumed to have a uniform cytoarchitecture. Differences in cerebellar function are thought to arise primarily through distinct patterns of input and output connectivity rather than as a result of variations in cortical microcircuitry. However, evidence from anatomical, physiological and genetic studies is increasingly challenging this orthodoxy, and there are now various lines of evidence indicating that the cerebellar cortex is not uniform. Here, we develop the hypothesis that regional differences in properties of cerebellar cortical microcircuits lead to important differences in information processing.

Original languageEnglish
Pages (from-to)79-93
Number of pages15
JournalNature Reviews Neuroscience
Volume16
Issue number2
DOIs
Publication statusPublished - 20 Jan 2015

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