Redox Transitions in an Electrolyte-Free Myoglobin Fluid

Kamendra Sharma; Adam Perriman; Kieren A Bradley; Alex P. S.  Brogan; Stephen Mann; David J Fermin

doi:10.1021/ja4104606

Redox Transitions in an Electrolyte-Free Myoglobin Fluid

Kamendra Sharma, Adam Perriman, Kieren A Bradley, Alex P. S. Brogan, Stephen Mann^*, David J Fermin

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

23 Citations (Scopus)

Abstract

Redox responses associated with the heme prosthetic group in a myoglobin-polymer surfactant solvent-free liquid are investigated for the first time in the absence of an electrolyte solution. Cyclic voltammograms from the biofluid exhibit responses that are consistent with planar diffusion of mobile charges in the melt. Temperature-dependent dynamic electrochemical and theological responses are rationalized in terms of the effective electron hopping rate between heme centers and the transport of intrinsic ionic species in the viscous protein liquid.

Original language	English
Pages (from-to)	18311-18314
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	135
Issue number	49
DOIs	https://doi.org/10.1021/ja4104606
Publication status	Published - 11 Dec 2013

Keywords

LAYER-BY-LAYER
BIOMEMBRANE-LIKE FILMS
FREE LIQUID MYOGLOBIN
DIRECT ELECTROCHEMISTRY
CYTOCHROME P450(CAM)
PROTEINS
MELTS

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Molten Proteins: synthesis and design of novel biomolecule-based liquid nanomaterials and their application in bionanochemistry
Mann, S. (Principal Investigator)
29/08/11 → 29/08/14
Project: Research
Chemical and biophysical studies of ionic protein fluids.
Perriman, A. W. (Principal Investigator)
1/05/10 → 1/05/13
Project: Research

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@article{334f2fa4c84e4034912d13a1a24ca26b,

title = "Redox Transitions in an Electrolyte-Free Myoglobin Fluid",

abstract = "Redox responses associated with the heme prosthetic group in a myoglobin-polymer surfactant solvent-free liquid are investigated for the first time in the absence of an electrolyte solution. Cyclic voltammograms from the biofluid exhibit responses that are consistent with planar diffusion of mobile charges in the melt. Temperature-dependent dynamic electrochemical and theological responses are rationalized in terms of the effective electron hopping rate between heme centers and the transport of intrinsic ionic species in the viscous protein liquid.",

keywords = "LAYER-BY-LAYER, BIOMEMBRANE-LIKE FILMS, FREE LIQUID MYOGLOBIN, DIRECT ELECTROCHEMISTRY, CYTOCHROME P450(CAM), PROTEINS, MELTS",

author = "Kamendra Sharma and Adam Perriman and Bradley, {Kieren A} and Brogan, {Alex P. S.} and Stephen Mann and Fermin, {David J}",

year = "2013",

month = dec,

day = "11",

doi = "10.1021/ja4104606",

language = "English",

volume = "135",

pages = "18311--18314",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

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TY - JOUR

T1 - Redox Transitions in an Electrolyte-Free Myoglobin Fluid

AU - Sharma, Kamendra

AU - Perriman, Adam

AU - Bradley, Kieren A

AU - Brogan, Alex P. S.

AU - Mann, Stephen

AU - Fermin, David J

PY - 2013/12/11

Y1 - 2013/12/11

N2 - Redox responses associated with the heme prosthetic group in a myoglobin-polymer surfactant solvent-free liquid are investigated for the first time in the absence of an electrolyte solution. Cyclic voltammograms from the biofluid exhibit responses that are consistent with planar diffusion of mobile charges in the melt. Temperature-dependent dynamic electrochemical and theological responses are rationalized in terms of the effective electron hopping rate between heme centers and the transport of intrinsic ionic species in the viscous protein liquid.

AB - Redox responses associated with the heme prosthetic group in a myoglobin-polymer surfactant solvent-free liquid are investigated for the first time in the absence of an electrolyte solution. Cyclic voltammograms from the biofluid exhibit responses that are consistent with planar diffusion of mobile charges in the melt. Temperature-dependent dynamic electrochemical and theological responses are rationalized in terms of the effective electron hopping rate between heme centers and the transport of intrinsic ionic species in the viscous protein liquid.

KW - LAYER-BY-LAYER

KW - BIOMEMBRANE-LIKE FILMS

KW - FREE LIQUID MYOGLOBIN

KW - DIRECT ELECTROCHEMISTRY

KW - CYTOCHROME P450(CAM)

KW - PROTEINS

KW - MELTS

U2 - 10.1021/ja4104606

DO - 10.1021/ja4104606

M3 - Article (Academic Journal)

C2 - 24245589

SN - 0002-7863

VL - 135

SP - 18311

EP - 18314

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 49

ER -

Redox Transitions in an Electrolyte-Free Myoglobin Fluid

Abstract

Keywords

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Projects

Molten Proteins: synthesis and design of novel biomolecule-based liquid nanomaterials and their application in bionanochemistry

Chemical and biophysical studies of ionic protein fluids.

Cite this