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Reduced Macular Vessel Density and Capillary Perfusion in Glaucoma Detected Using OCT Angiography

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Reduced Macular Vessel Density and Capillary Perfusion in Glaucoma Detected Using OCT Angiography. / Wu, Jiahui; Sebastian, Rani T.; Chu, Colin J.; McGregor, Freia; Dick, Andrew D.; Liu, Lei.

In: Current Eye Research, Vol. 44, No. 5, 04.05.2019, p. 533-540.

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Wu, J, Sebastian, RT, Chu, CJ, McGregor, F, Dick, AD & Liu, L 2019, 'Reduced Macular Vessel Density and Capillary Perfusion in Glaucoma Detected Using OCT Angiography', Current Eye Research, vol. 44, no. 5, pp. 533-540. https://doi.org/10.1080/02713683.2018.1563195

APA

Wu, J., Sebastian, R. T., Chu, C. J., McGregor, F., Dick, A. D., & Liu, L. (2019). Reduced Macular Vessel Density and Capillary Perfusion in Glaucoma Detected Using OCT Angiography. Current Eye Research, 44(5), 533-540. https://doi.org/10.1080/02713683.2018.1563195

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Wu, Jiahui ; Sebastian, Rani T. ; Chu, Colin J. ; McGregor, Freia ; Dick, Andrew D. ; Liu, Lei. / Reduced Macular Vessel Density and Capillary Perfusion in Glaucoma Detected Using OCT Angiography. In: Current Eye Research. 2019 ; Vol. 44, No. 5. pp. 533-540.

Bibtex

@article{c3474274b75b431383ca76d1410e3d28,
title = "Reduced Macular Vessel Density and Capillary Perfusion in Glaucoma Detected Using OCT Angiography",
abstract = "AIMS: To evaluate retinal vasculature changes in primary open angle glaucoma (POAG) and whether the functional visual loss correlates with parameters obtained using optical coherence tomography angiography (OCTA).MATERIALS AND METHODS: OCT and OCTA images were collected from 116 POAG eyes and 40 normal eyes in a prospective, cross-sectional observational study. Glaucomatous eyes were further divided into three groups according to a Glaucoma Staging System. Measurements of macular vessel density, ganglion cell complex (GCC), and disc retinal nerve fibre layer (RNFL) thickness were compared among groups.RESULTS: The macular vessel density, GCC, and RNFL are significantly reduced in POAG compared to normal eyes that also corresponds to the severity of glaucoma (Kruskal-Wallis test with Dunnett's correction; p < 0.0001). Visual field mean deviation correlates significantly with macular vessel density (p = 0.0028, r = 0.3), GCC (p < 0.0001, r = 0.6), and RNFL (p = 0.008, r = 0.36) in POAG. There are significant correlations between GCC and RNFL (p < 0.0001, r = 0.76) as well as macular vessel density (p < 0.0001, r = 0.48). Increased age also correlates with reduced macular vessel density in both normal (p = 0.0002, r = 0.49) and glaucomatous eyes (p < 0.0001, r = 0.48), but a greater proportionate reduction of vessel density is seen in glaucomatous eyes.CONCLUSION: Reduced macular vessel density occurs in POAG despite of age-related changes, which also correlates with reductions in RNFL and GCC measurements. OCTA can detect microstructural defects and offers potential to facilitate diagnosis of glaucoma.",
keywords = "Glaucoma, intraocular pressure, macula, field of vision, optic nerve, OCTA",
author = "Jiahui Wu and Sebastian, {Rani T.} and Chu, {Colin J.} and Freia McGregor and Dick, {Andrew D.} and Lei Liu",
year = "2019",
month = "5",
day = "4",
doi = "10.1080/02713683.2018.1563195",
language = "English",
volume = "44",
pages = "533--540",
journal = "Current Eye Research",
issn = "0271-3683",
publisher = "Taylor & Francis Group",
number = "5",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Reduced Macular Vessel Density and Capillary Perfusion in Glaucoma Detected Using OCT Angiography

AU - Wu, Jiahui

AU - Sebastian, Rani T.

AU - Chu, Colin J.

AU - McGregor, Freia

AU - Dick, Andrew D.

AU - Liu, Lei

PY - 2019/5/4

Y1 - 2019/5/4

N2 - AIMS: To evaluate retinal vasculature changes in primary open angle glaucoma (POAG) and whether the functional visual loss correlates with parameters obtained using optical coherence tomography angiography (OCTA).MATERIALS AND METHODS: OCT and OCTA images were collected from 116 POAG eyes and 40 normal eyes in a prospective, cross-sectional observational study. Glaucomatous eyes were further divided into three groups according to a Glaucoma Staging System. Measurements of macular vessel density, ganglion cell complex (GCC), and disc retinal nerve fibre layer (RNFL) thickness were compared among groups.RESULTS: The macular vessel density, GCC, and RNFL are significantly reduced in POAG compared to normal eyes that also corresponds to the severity of glaucoma (Kruskal-Wallis test with Dunnett's correction; p < 0.0001). Visual field mean deviation correlates significantly with macular vessel density (p = 0.0028, r = 0.3), GCC (p < 0.0001, r = 0.6), and RNFL (p = 0.008, r = 0.36) in POAG. There are significant correlations between GCC and RNFL (p < 0.0001, r = 0.76) as well as macular vessel density (p < 0.0001, r = 0.48). Increased age also correlates with reduced macular vessel density in both normal (p = 0.0002, r = 0.49) and glaucomatous eyes (p < 0.0001, r = 0.48), but a greater proportionate reduction of vessel density is seen in glaucomatous eyes.CONCLUSION: Reduced macular vessel density occurs in POAG despite of age-related changes, which also correlates with reductions in RNFL and GCC measurements. OCTA can detect microstructural defects and offers potential to facilitate diagnosis of glaucoma.

AB - AIMS: To evaluate retinal vasculature changes in primary open angle glaucoma (POAG) and whether the functional visual loss correlates with parameters obtained using optical coherence tomography angiography (OCTA).MATERIALS AND METHODS: OCT and OCTA images were collected from 116 POAG eyes and 40 normal eyes in a prospective, cross-sectional observational study. Glaucomatous eyes were further divided into three groups according to a Glaucoma Staging System. Measurements of macular vessel density, ganglion cell complex (GCC), and disc retinal nerve fibre layer (RNFL) thickness were compared among groups.RESULTS: The macular vessel density, GCC, and RNFL are significantly reduced in POAG compared to normal eyes that also corresponds to the severity of glaucoma (Kruskal-Wallis test with Dunnett's correction; p < 0.0001). Visual field mean deviation correlates significantly with macular vessel density (p = 0.0028, r = 0.3), GCC (p < 0.0001, r = 0.6), and RNFL (p = 0.008, r = 0.36) in POAG. There are significant correlations between GCC and RNFL (p < 0.0001, r = 0.76) as well as macular vessel density (p < 0.0001, r = 0.48). Increased age also correlates with reduced macular vessel density in both normal (p = 0.0002, r = 0.49) and glaucomatous eyes (p < 0.0001, r = 0.48), but a greater proportionate reduction of vessel density is seen in glaucomatous eyes.CONCLUSION: Reduced macular vessel density occurs in POAG despite of age-related changes, which also correlates with reductions in RNFL and GCC measurements. OCTA can detect microstructural defects and offers potential to facilitate diagnosis of glaucoma.

KW - Glaucoma

KW - intraocular pressure

KW - macula

KW - field of vision

KW - optic nerve

KW - OCTA

UR - http://www.scopus.com/inward/record.url?scp=85059525454&partnerID=8YFLogxK

U2 - 10.1080/02713683.2018.1563195

DO - 10.1080/02713683.2018.1563195

M3 - Article

VL - 44

SP - 533

EP - 540

JO - Current Eye Research

JF - Current Eye Research

SN - 0271-3683

IS - 5

ER -