Refined views of multi-protein complexes in the erythrocyte membrane

T J Mankelow, T J Satchwell, N M Burton

Research output: Contribution to journalArticle (Academic Journal)peer-review

35 Citations (Scopus)

Abstract

The erythrocyte membrane has been extensively studied, both as a model membrane system and to investigate its role in gas exchange and transport. Much is now known about the protein components of the membrane, how they are organised into large multi-protein complexes and how they interact with each other within these complexes. Many links between the membrane and the cytoskeleton have also been delineated and have been demonstrated to be crucial for maintaining the deformability and integrity of the erythrocyte. In this study we have refined previous, highly speculative molecular models of these complexes by including the available data pertaining to known protein-protein interactions. While the refined models remain highly speculative, they provide an evolving framework for visualisation of these important cellular structures at the atomic level.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalBlood Cells, Molecules, and Diseases
Volume49
Issue number1
DOIs
Publication statusPublished - 15 Jun 2012

Keywords

  • Animals
  • Biological Transport
  • Erythrocyte Membrane
  • Humans
  • Membrane Proteins
  • Models, Biological
  • Multiprotein Complexes

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