Region-specific loss of glutamate innervation in Alzheimer's disease

J Hardy; R Cowburn; A Barton; G Reynolds; E Lofdahl; A M O'Carroll; P Wester; B Winblad

Region-specific loss of glutamate innervation in Alzheimer's disease

J Hardy, R Cowburn, A Barton, G Reynolds, E Lofdahl, A M O'Carroll, P Wester, B Winblad

Research output: Contribution to journal › Article (Academic Journal) › peer-review

104 Citations (Scopus)

Abstract

Synaptosomal D-aspartate has been used as a marker for glutamate neurons in control and in postmortem Alzheimer's disease brains. This technique shows a marked (60%) decrease of the glutamate uptake site in cortical and hippocampal regions. There were no significant changes in subcortical regions. We interpret these results as indicating loss of, or damage to, cortical glutamatergic innervation. These losses probably represent the biochemical correlate of pyramidal neuron damage in Alzheimer's disease.

Original language	English
Pages (from-to)	77-80
Number of pages	4
Journal	Neuroscience Letters
Volume	73
Issue number	1
Publication status	Published - 2 Jan 1987

Keywords

Alzheimer Disease
Aspartic Acid
Brain
Cerebral Cortex
Glutamates
Glutamic Acid
Hippocampus
Humans
Synaptosomes

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title = "Region-specific loss of glutamate innervation in Alzheimer's disease",

abstract = "Synaptosomal D-aspartate has been used as a marker for glutamate neurons in control and in postmortem Alzheimer's disease brains. This technique shows a marked (60%) decrease of the glutamate uptake site in cortical and hippocampal regions. There were no significant changes in subcortical regions. We interpret these results as indicating loss of, or damage to, cortical glutamatergic innervation. These losses probably represent the biochemical correlate of pyramidal neuron damage in Alzheimer's disease.",

keywords = "Alzheimer Disease, Aspartic Acid, Brain, Cerebral Cortex, Glutamates, Glutamic Acid, Hippocampus, Humans, Synaptosomes",

author = "J Hardy and R Cowburn and A Barton and G Reynolds and E Lofdahl and O'Carroll, {A M} and P Wester and B Winblad",

year = "1987",

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T1 - Region-specific loss of glutamate innervation in Alzheimer's disease

AU - Hardy, J

AU - Cowburn, R

AU - Barton, A

AU - Reynolds, G

AU - Lofdahl, E

AU - O'Carroll, A M

AU - Wester, P

AU - Winblad, B

PY - 1987/1/2

Y1 - 1987/1/2

N2 - Synaptosomal D-aspartate has been used as a marker for glutamate neurons in control and in postmortem Alzheimer's disease brains. This technique shows a marked (60%) decrease of the glutamate uptake site in cortical and hippocampal regions. There were no significant changes in subcortical regions. We interpret these results as indicating loss of, or damage to, cortical glutamatergic innervation. These losses probably represent the biochemical correlate of pyramidal neuron damage in Alzheimer's disease.

AB - Synaptosomal D-aspartate has been used as a marker for glutamate neurons in control and in postmortem Alzheimer's disease brains. This technique shows a marked (60%) decrease of the glutamate uptake site in cortical and hippocampal regions. There were no significant changes in subcortical regions. We interpret these results as indicating loss of, or damage to, cortical glutamatergic innervation. These losses probably represent the biochemical correlate of pyramidal neuron damage in Alzheimer's disease.

KW - Alzheimer Disease

KW - Aspartic Acid

KW - Brain

KW - Cerebral Cortex

KW - Glutamates

KW - Glutamic Acid

KW - Hippocampus

KW - Humans

KW - Synaptosomes

M3 - Article (Academic Journal)

C2 - 2882446

VL - 73

SP - 77

EP - 80

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1

ER -