Region-specific loss of glutamate innervation in Alzheimer's disease

J Hardy, R Cowburn, A Barton, G Reynolds, E Lofdahl, A M O'Carroll, P Wester, B Winblad

Research output: Contribution to journalArticle (Academic Journal)peer-review

104 Citations (Scopus)


Synaptosomal D-aspartate has been used as a marker for glutamate neurons in control and in postmortem Alzheimer's disease brains. This technique shows a marked (60%) decrease of the glutamate uptake site in cortical and hippocampal regions. There were no significant changes in subcortical regions. We interpret these results as indicating loss of, or damage to, cortical glutamatergic innervation. These losses probably represent the biochemical correlate of pyramidal neuron damage in Alzheimer's disease.

Original languageEnglish
Pages (from-to)77-80
Number of pages4
JournalNeuroscience Letters
Issue number1
Publication statusPublished - 2 Jan 1987


  • Alzheimer Disease
  • Aspartic Acid
  • Brain
  • Cerebral Cortex
  • Glutamates
  • Glutamic Acid
  • Hippocampus
  • Humans
  • Synaptosomes

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