Projects per year
Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that currently affects 36 million people worldwide with no effective treatment available. Development of AD follows a distinctive pattern in the brain and is poorly modelled in animals. Therefore, it is vital to widen the spatial scope of the study of AD and prioritise the study of human brains. Here we show that functionally distinct human brain regions display varying and region-specific changes in protein expression. These changes provide insights into the progression of disease, novel AD-related pathways, the presence of a gradient of protein expression change from less to more affected regions and a possibly protective protein expression profile in the cerebellum. This spatial proteomics analysis provides a framework which can underpin current research and open new avenues to enhance molecular understanding of AD pathophysiology, provide new targets for intervention and broaden the conceptual frameworks for future AD research.
Original language | English |
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Article number | 43 (2019) |
Number of pages | 15 |
Journal | Communications Biology |
Volume | 2 |
DOIs | |
Publication status | Published - 4 Feb 2019 |
Keywords
- Alzheimer's disease
- Proteome
- Proteomic analysis
- Proteomics
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Dive into the research topics of 'Regional protein expression in human Alzheimer's brain correlates with disease severity'. Together they form a unique fingerprint.Projects
- 2 Finished
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A holistic statistical modelling approach to quantitative discovery proteonics and metabolomics for underpinning integrative systems medicine
Dowsey, A. (Principal Investigator)
1/07/16 → 31/10/17
Project: Research
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Bilateral NSF/BIO-BBSRC: Bayesian Quantitative Proteomics
Dowsey, A. (Principal Investigator)
1/07/16 → 31/03/19
Project: Research
Profiles
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Professor Andrew Dowsey
- Bristol Veterinary School - Chair in One Health Data Science
- Bristol Population Health Science Institute
Person: Academic , Member