Regional protein expression in human Alzheimer's brain correlates with disease severity

Jingshu Xu, Stefano Patassini, Nitin Rustogi, Isabel Riba-Garcia, Benjamin D. Hale, Alexander M. Phillips, Henry Waldvogel, Robert Haines, Phil Bradbury, Adam Stevens, Richard L.M. Faull, Andrew W. Dowsey, Garth J.S. Cooper, Richard D. Unwin*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

39 Citations (Scopus)
216 Downloads (Pure)

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that currently affects 36 million people worldwide with no effective treatment available. Development of AD follows a distinctive pattern in the brain and is poorly modelled in animals. Therefore, it is vital to widen the spatial scope of the study of AD and prioritise the study of human brains. Here we show that functionally distinct human brain regions display varying and region-specific changes in protein expression. These changes provide insights into the progression of disease, novel AD-related pathways, the presence of a gradient of protein expression change from less to more affected regions and a possibly protective protein expression profile in the cerebellum. This spatial proteomics analysis provides a framework which can underpin current research and open new avenues to enhance molecular understanding of AD pathophysiology, provide new targets for intervention and broaden the conceptual frameworks for future AD research.

Original languageEnglish
Article number43 (2019)
Number of pages15
JournalCommunications Biology
Volume2
DOIs
Publication statusPublished - 4 Feb 2019

Keywords

  • Alzheimer's disease
  • Proteome
  • Proteomic analysis
  • Proteomics

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