Regionally selective requirement for D1-D5 dopaminergic neurotransmisson in the medial prefrontal cortex in object-in-place associative recognition memorty: dopamine and object-in-place memory

Giorgia Savalli, Zafar I Bashir, Clea Warburton

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)
185 Downloads (Pure)

Abstract

Object-in-place (OiP) memory is critical for remembering the location in which an object was last encountered and depends conjointly on the medial prefrontal cortex, perirhinal cortex, and hippocampus. Here we examined the role of dopamine D1/D5 receptor neurotransmission within these brain regions for OiP memory. Bilateral infusion of D1/D5 receptor antagonists SCH23390 or SKF83566 into the medial prefrontal cortex, prior to memory acquisition, impaired OiP performance following a 5 min or 1 h delay. Retrieval was unaffected. Intraperirhinal or intrahippocampal infusions of SCH23390 had no effect. These results reveal a selective role for D1/D5 receptors in the mPFC during OiP memory encoding.
Original languageEnglish
Pages (from-to)69-73
Number of pages5
JournalLearning and Memory
Volume22
Issue number2
Early online date15 Jan 2015
DOIs
Publication statusPublished - Feb 2015

Keywords

  • recognition memory
  • perirhinal cortex
  • prefrontal cortex
  • hippocampus
  • dopamine
  • rat

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