Regulating Rho GTPases and their regulators

Richard G Hodge, Anne J Ridley

Research output: Contribution to journalReview article (Academic Journal)

Abstract

Rho GTPases regulate cytoskeletal and cell adhesion dynamics and thereby coordinate a wide range of cellular processes, including cell migration, cell polarity and cell cycle progression. Most Rho GTPases cycle between a GTP-bound active conformation and a GDP-bound inactive conformation to regulate their ability to activate effector proteins and to elicit cellular responses. However, it has become apparent that Rho GTPases are regulated by post-translational modifications and the formation of specific protein complexes, in addition to GTP-GDP cycling. The canonical regulators of Rho GTPases - guanine nucleotide exchange factors, GTPase-activating proteins and guanine nucleotide dissociation inhibitors - are regulated similarly, creating a complex network of interactions to determine the precise spatiotemporal activation of Rho GTPases.

Original languageEnglish
Pages (from-to)496-510
Number of pages15
JournalNature Reviews Molecular Cell Biology
Volume17
Issue number8
Early online date15 Jun 2016
DOIs
Publication statusPublished - Aug 2016

Keywords

  • Animals
  • Humans
  • Protein Processing, Post-Translational
  • rho GTP-Binding Proteins
  • Journal Article
  • Review

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