Relationship between adenovirus DNA replication proteins and nucleolar proteins B23.1 and B23.2

Research output: Contribution to journalArticle (Academic Journal)peer-review

20 Citations (Scopus)

Abstract

Adenovirus infection subverts nucleolar structure and function. B23 is a nucleolar protein present in two isoforms (B23.1 and B23.2) and both isoforms have been identified as stimulatory factors for adenovirus DNA replication. Here, it is demonstrated that the two isoforms of B23, B23.1 and B23.2, interact and co-localize differently with viral DNA replication proteins pTP and DBP in adenovirus-infected cells. Thus, the mechanism by which the two proteins stimulate viral DNA replication is likely to differ. These data also demonstrate the importance of testing both isoforms of B23 for interactions with viral proteins and nucleic acids.
Translated title of the contributionRelationship between adenovirus DNA replication proteins and nucleolar proteins B23.1 and B23.2
Original languageEnglish
Pages (from-to)3244 - 3248
Number of pages5
JournalJournal of General Virology
Volume88 (12)
DOIs
Publication statusPublished - Dec 2007

Bibliographical note

Publisher: Society for General Microbiology

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