Relationship between taste thresholds and antidepressant response: Preliminary findings

S. Srivastava; A. Kumar; V. Agarwal; P. Chubey; L. Donaldson; J. Potokar

doi:10.1016/j.eurpsy.2017.02.384

Relationship between taste thresholds and antidepressant response: Preliminary findings

S. Srivastava, A. Kumar, V. Agarwal, P. Chubey, L. Donaldson, J. Potokar

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Abstract

Introduction

In healthy volunteers, light acting through serotonin pathways, decreases the threshold for sweet, but not salt taste; similar to SSRI paroxetine. In depressive disorders, there is deficiency of serotonin throughput, which is remedied by SSRI medications, and results in improvement in symptoms of depression. Thus, we report on taste thresholds before and after SSRI treatment.

Objectives

To study the variation in thresholds for sweet with SSRI treatment in depressed patients in short- and long-term.

Aims

To compare the threshold for sweet (test) and salt (control) after 1 and 4 weeks of SSRI escitalopram therapy in depressed patients.

Methods

The project was approved by the institutional ethics committee. Following informed consent, depressed patients were initiated on escitalopram 10 mg/d (increased to 15 or 20 mg, if required after 1 week,). Taste recognition threshold, intensity and pleasantness were measured for sweet and salt. Each tastant was made −1 to −3 (100 mM–1 mM). Regional recognition thresholds were determined at the tip of the tongue using a cotton bud well soaked in the tastant.

Results

Three males and 4 females of mean ages 39.1 years completed the study. There was significant shift to the left for sweet thresholds between days 0 and 7, and 7 and 28 [F(Dfn, Dfd) = 9.242 (4.162) P < 0.0001]. A similar shift to the left was seen for salt but day 7 only [F(Dfn, Dfd) = 6.213 (4.162)].

Conclusion

The increase in serotonin throughput as envisaged through SSRI treatment was paralleled by decrease in sweet thresholds.

Original language	English
Pages (from-to)	S371-S372
Number of pages	2
Journal	European Psychiatry
Volume	41, Supplement
Early online date	30 Jun 2017
DOIs	https://doi.org/10.1016/j.eurpsy.2017.02.384
Publication status	Published - 2017

Bibliographical note

Special issue: Abstract of the 25th European Congress of Psychiatry

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10.1016/j.eurpsy.2017.02.384

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@article{dba36c6fa5ef41e9a9b0faa41a3dbbed,

title = "Relationship between taste thresholds and antidepressant response: Preliminary findings",

abstract = "IntroductionIn healthy volunteers, light acting through serotonin pathways, decreases the threshold for sweet, but not salt taste; similar to SSRI paroxetine. In depressive disorders, there is deficiency of serotonin throughput, which is remedied by SSRI medications, and results in improvement in symptoms of depression. Thus, we report on taste thresholds before and after SSRI treatment.ObjectivesTo study the variation in thresholds for sweet with SSRI treatment in depressed patients in short- and long-term.AimsTo compare the threshold for sweet (test) and salt (control) after 1 and 4 weeks of SSRI escitalopram therapy in depressed patients.MethodsThe project was approved by the institutional ethics committee. Following informed consent, depressed patients were initiated on escitalopram 10 mg/d (increased to 15 or 20 mg, if required after 1 week,). Taste recognition threshold, intensity and pleasantness were measured for sweet and salt. Each tastant was made −1 to −3 (100 mM–1 mM). Regional recognition thresholds were determined at the tip of the tongue using a cotton bud well soaked in the tastant.ResultsThree males and 4 females of mean ages 39.1 years completed the study. There was significant shift to the left for sweet thresholds between days 0 and 7, and 7 and 28 [F(Dfn, Dfd) = 9.242 (4.162) P < 0.0001]. A similar shift to the left was seen for salt but day 7 only [F(Dfn, Dfd) = 6.213 (4.162)].ConclusionThe increase in serotonin throughput as envisaged through SSRI treatment was paralleled by decrease in sweet thresholds.",

author = "S. Srivastava and A. Kumar and V. Agarwal and P. Chubey and L. Donaldson and J. Potokar",

note = "Special issue: Abstract of the 25th European Congress of Psychiatry",

year = "2017",

doi = "10.1016/j.eurpsy.2017.02.384",

language = "English",

volume = "41, Supplement",

pages = "S371--S372",

journal = "European Psychiatry",

issn = "0924-9338",

publisher = "Elsevier",

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TY - JOUR

T1 - Relationship between taste thresholds and antidepressant response: Preliminary findings

AU - Srivastava, S.

AU - Kumar, A.

AU - Agarwal, V.

AU - Chubey, P.

AU - Donaldson, L.

AU - Potokar, J.

N1 - Special issue: Abstract of the 25th European Congress of Psychiatry

PY - 2017

Y1 - 2017

N2 - IntroductionIn healthy volunteers, light acting through serotonin pathways, decreases the threshold for sweet, but not salt taste; similar to SSRI paroxetine. In depressive disorders, there is deficiency of serotonin throughput, which is remedied by SSRI medications, and results in improvement in symptoms of depression. Thus, we report on taste thresholds before and after SSRI treatment.ObjectivesTo study the variation in thresholds for sweet with SSRI treatment in depressed patients in short- and long-term.AimsTo compare the threshold for sweet (test) and salt (control) after 1 and 4 weeks of SSRI escitalopram therapy in depressed patients.MethodsThe project was approved by the institutional ethics committee. Following informed consent, depressed patients were initiated on escitalopram 10 mg/d (increased to 15 or 20 mg, if required after 1 week,). Taste recognition threshold, intensity and pleasantness were measured for sweet and salt. Each tastant was made −1 to −3 (100 mM–1 mM). Regional recognition thresholds were determined at the tip of the tongue using a cotton bud well soaked in the tastant.ResultsThree males and 4 females of mean ages 39.1 years completed the study. There was significant shift to the left for sweet thresholds between days 0 and 7, and 7 and 28 [F(Dfn, Dfd) = 9.242 (4.162) P < 0.0001]. A similar shift to the left was seen for salt but day 7 only [F(Dfn, Dfd) = 6.213 (4.162)].ConclusionThe increase in serotonin throughput as envisaged through SSRI treatment was paralleled by decrease in sweet thresholds.

AB - IntroductionIn healthy volunteers, light acting through serotonin pathways, decreases the threshold for sweet, but not salt taste; similar to SSRI paroxetine. In depressive disorders, there is deficiency of serotonin throughput, which is remedied by SSRI medications, and results in improvement in symptoms of depression. Thus, we report on taste thresholds before and after SSRI treatment.ObjectivesTo study the variation in thresholds for sweet with SSRI treatment in depressed patients in short- and long-term.AimsTo compare the threshold for sweet (test) and salt (control) after 1 and 4 weeks of SSRI escitalopram therapy in depressed patients.MethodsThe project was approved by the institutional ethics committee. Following informed consent, depressed patients were initiated on escitalopram 10 mg/d (increased to 15 or 20 mg, if required after 1 week,). Taste recognition threshold, intensity and pleasantness were measured for sweet and salt. Each tastant was made −1 to −3 (100 mM–1 mM). Regional recognition thresholds were determined at the tip of the tongue using a cotton bud well soaked in the tastant.ResultsThree males and 4 females of mean ages 39.1 years completed the study. There was significant shift to the left for sweet thresholds between days 0 and 7, and 7 and 28 [F(Dfn, Dfd) = 9.242 (4.162) P < 0.0001]. A similar shift to the left was seen for salt but day 7 only [F(Dfn, Dfd) = 6.213 (4.162)].ConclusionThe increase in serotonin throughput as envisaged through SSRI treatment was paralleled by decrease in sweet thresholds.

U2 - 10.1016/j.eurpsy.2017.02.384

DO - 10.1016/j.eurpsy.2017.02.384

M3 - Article (Academic Journal)

VL - 41, Supplement

SP - S371-S372

JO - European Psychiatry

JF - European Psychiatry

SN - 0924-9338

ER -