Relationships of urinary adrenal steroids at age 8 years with birth weight, postnatel growth blood pressure and glucose metabolism

JW Honour, R Jones, SD Leary, J Golding, KK Ong, DB Dungar

Research output: Contribution to journalArticle (Academic Journal)

Abstract

Introduction: Overactivity of the hypothalamic-pituitary-adrenal axis through a program set by early growth patterns is hypothesized to lead to central obesity, insulin resistance, and hypertension. We therefore examined links between adrenal steroid production and birth weight, rapid early growth, and body mass index (BMI), blood pressure, waist circumference, and resistance to insulin in early childhood through the action of adrenal steroids.

Methods: Timed overnight urine samples were collected in 461 children from a large representative birth cohort. In total 244 boys and 188 girls aged 8.2–8.4 yr completed the protocol. The excretion rates of individual steroids were measured to determine total androgen and cortisol metabolites. Indices of activity of 5α-androgen reduction of androgens and cortisol metabolites and 11β-hydroxy steroid dehydrogenase activity were calculated.

Results: In both boys and girls, total urinary androgen and cortisol metabolites were positively related to current height, weight, BMI, and waist circumference. Girls had higher urine androgen metabolite levels and 5α-androgen indexes than boys, and in girls higher androgen metabolite excretion was associated with lower birth weight and faster postnatal weight gain. After adjustment for current BMI, total cortisol metabolites and 11β-hydroxy steroid dehydrogenase index were not related to birth weight or postnatal weight gain in either sex.

Conclusions: These data confirm early growth associations in this cohort seen with plasma levels of adrenal androgens at age 8 yr, at least in girls. Larger studies and follow-up during puberty are needed to exclude the possibility of programming of cortisol metabolism by early growth.
Translated title of the contributionRelationships of urinary adrenal steroids at age 8 years with birth weight, postnatel growth blood pressure and glucose metabolism
Original languageEnglish
Pages (from-to)4340 - 4345
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume92
Publication statusPublished - 2007

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