Relative efficacy of treatment options in transplant-ineligible newly diagnosed multiple myeloma: results from a systematic literature review and network meta-analysis

Karthik Ramasamy, Sujith Dhanasiri, Howard Thom, Vanessa Buchanan, Suzanne Robinson, Vijay K. D'Souza, Katja Weisel

Research output: Contribution to journalArticle (Academic Journal)peer-review

2 Citations (Scopus)
125 Downloads (Pure)

Abstract

Established treatments for transplant-ineligible (TNE) patients with newly diagnosed multiple myeloma (NDMM) include melphalan and prednisone (MP) combined with either bortezomib (VMP) or thalidomide (MPT), or lenalidomide plus low-dose dexamethasone (Rd). New treatments for TNE NDMM include Rd plus bortezomib (RVd) and daratumumab plus VMP (VMP + D), daratumumab plus lenalidomide and dexamethasone (D + Rd). Relative efficacy of these treatments was compared using a network meta-analysis. Eight trials identified by a systematic literature review were included in the primary analysis; hazard ratios (HRs) for overall survival (OS) and progression-free survival (PFS) were used. Rd was superior to other MP-based regimens for OS and PFS. There was strong evidence that, compared with Rd, both D + Rd and RVd improved PFS (HR 0.57; 95% credible interval (CrI) 0.43, 0.73 and HR 0.72; 95% CrI 0.56, 0.91, respectively). However, there was strong evidence only for RVd in respect to OS (HR 0.72; 95% CrI 0.52, 0.96).
Original languageEnglish
Number of pages12
JournalLeukemia and Lymphoma
DOIs
Publication statusPublished - 11 Nov 2019

Keywords

  • multiple myeloma
  • network meta-analysis
  • systematic literature review
  • treatment-naive

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