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Release of filamentous and spherical influenza A virus is not restricted by tetherin

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Release of filamentous and spherical influenza A virus is not restricted by tetherin. / Bruce, EA; Abbink, TE; Wise, HM; Rollason, R; Galao, RP; Banting, G; Neil, SJ; Digard, P.

In: Journal of General Virology, Vol. 93(5), 05.2012, p. 963 - 969.

Research output: Contribution to journalArticle

Harvard

Bruce, EA, Abbink, TE, Wise, HM, Rollason, R, Galao, RP, Banting, G, Neil, SJ & Digard, P 2012, 'Release of filamentous and spherical influenza A virus is not restricted by tetherin', Journal of General Virology, vol. 93(5), pp. 963 - 969. https://doi.org/10.1099/vir.0.038778-0

APA

Bruce, EA., Abbink, TE., Wise, HM., Rollason, R., Galao, RP., Banting, G., ... Digard, P. (2012). Release of filamentous and spherical influenza A virus is not restricted by tetherin. Journal of General Virology, 93(5), 963 - 969. https://doi.org/10.1099/vir.0.038778-0

Vancouver

Bruce EA, Abbink TE, Wise HM, Rollason R, Galao RP, Banting G et al. Release of filamentous and spherical influenza A virus is not restricted by tetherin. Journal of General Virology. 2012 May;93(5):963 - 969. https://doi.org/10.1099/vir.0.038778-0

Author

Bruce, EA ; Abbink, TE ; Wise, HM ; Rollason, R ; Galao, RP ; Banting, G ; Neil, SJ ; Digard, P. / Release of filamentous and spherical influenza A virus is not restricted by tetherin. In: Journal of General Virology. 2012 ; Vol. 93(5). pp. 963 - 969.

Bibtex

@article{1fcbafb2dfc648268f594661fcd00685,
title = "Release of filamentous and spherical influenza A virus is not restricted by tetherin",
abstract = "The cellular protein tetherin is thought to act as a 'leash' that anchors many enveloped viruses to the plasma membrane and prevents their release. We found that replication of multiple strains of influenza A virus was generally insensitive to alteration of tetherin levels, as assessed by output titre or scanning electron microscopy of cell associated virions. This included human, swine, avian and equine isolates, strains that form filamentous or spherical particles and viruses that lack the M2 or NS1 proteins. Levels of cell-surface tetherin were not reduced by influenza infection, but tetherin and the viral hemagglutinin colocalised on the plasma membrane. However, tetherin could not be detected in filamentous virions, suggesting that influenza may possess a mechanism to exclude it from virions. Overall, if influenza does encode a specific antagonist of tetherin, it is not M2 or NS1 and we find no evidence for a role in host range specificity.",
author = "EA Bruce and TE Abbink and HM Wise and R Rollason and RP Galao and G Banting and SJ Neil and P Digard",
note = "Other: First published on-line 18th January 2012",
year = "2012",
month = "5",
doi = "10.1099/vir.0.038778-0",
language = "English",
volume = "93(5)",
pages = "963 -- 969",
journal = "Journal of General Virology",
issn = "0022-1317",
publisher = "Society for General Microbiology",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Release of filamentous and spherical influenza A virus is not restricted by tetherin

AU - Bruce, EA

AU - Abbink, TE

AU - Wise, HM

AU - Rollason, R

AU - Galao, RP

AU - Banting, G

AU - Neil, SJ

AU - Digard, P

N1 - Other: First published on-line 18th January 2012

PY - 2012/5

Y1 - 2012/5

N2 - The cellular protein tetherin is thought to act as a 'leash' that anchors many enveloped viruses to the plasma membrane and prevents their release. We found that replication of multiple strains of influenza A virus was generally insensitive to alteration of tetherin levels, as assessed by output titre or scanning electron microscopy of cell associated virions. This included human, swine, avian and equine isolates, strains that form filamentous or spherical particles and viruses that lack the M2 or NS1 proteins. Levels of cell-surface tetherin were not reduced by influenza infection, but tetherin and the viral hemagglutinin colocalised on the plasma membrane. However, tetherin could not be detected in filamentous virions, suggesting that influenza may possess a mechanism to exclude it from virions. Overall, if influenza does encode a specific antagonist of tetherin, it is not M2 or NS1 and we find no evidence for a role in host range specificity.

AB - The cellular protein tetherin is thought to act as a 'leash' that anchors many enveloped viruses to the plasma membrane and prevents their release. We found that replication of multiple strains of influenza A virus was generally insensitive to alteration of tetherin levels, as assessed by output titre or scanning electron microscopy of cell associated virions. This included human, swine, avian and equine isolates, strains that form filamentous or spherical particles and viruses that lack the M2 or NS1 proteins. Levels of cell-surface tetherin were not reduced by influenza infection, but tetherin and the viral hemagglutinin colocalised on the plasma membrane. However, tetherin could not be detected in filamentous virions, suggesting that influenza may possess a mechanism to exclude it from virions. Overall, if influenza does encode a specific antagonist of tetherin, it is not M2 or NS1 and we find no evidence for a role in host range specificity.

U2 - 10.1099/vir.0.038778-0

DO - 10.1099/vir.0.038778-0

M3 - Article

VL - 93(5)

SP - 963

EP - 969

JO - Journal of General Virology

JF - Journal of General Virology

SN - 0022-1317

ER -