RelTime rates collapse to a strict clock when estimating the timeline of animal diversification

Jesus Lozano-Fernandez, Mario dos Reis, Philip Donoghue*, Davide Pisani

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

17 Citations (Scopus)
239 Downloads (Pure)

Abstract

Establishing an accurate timescale for the history of life is crucial to understand evolutionary processes. To this scope, relaxed molecular clock models implemented in a Bayesian MCMC framework are generally used. However, these methods are time consuming. RelTime, a non-Bayesian method implementing a fast, ad hoc, algorithm for relative dating, was developed to overcome the computational inefficiencies of Bayesian software. RelTime was recently used to investigate the origin of animals, and found results consistent with outdated studies from the 1980es and 1990es that recovered metazoans to have a Mesoproterozoic origin (originating approximately 1.5 Billion years ago) based on a strict clock model. RelTime results are unexpected and disagree with the largest majority of modern, relaxed, Bayesian molecular clock analyses, that suggest animals originated in the Tonian-Cryogenian (less than 850 millions of years ago) instead. Here, we demonstrate that RelTime-inferred divergence times for the origin of animals are erroneous, a consequence of the inability of RelTime to relax the clock along the internal branches of the animal phylogeny. RelTime-inferred divergence times are comparable to strict-clock estimates because they are essentially inferred under a strict clock. Our results warn us of the danger of using ad hoc algorithms making implicit, unclear, assumptions about rate changes along a tree. Our study reject the existence of Mesoproterozioc animals. Metazoans emerged in the Tonian-Cryogenian, and diversified in the Ediacaran, in the immediate prelude to the routine fossilization of animals in the Cambrian associated with the emergence of readily preserved skeletons.
Original languageEnglish
Article numberevx079
Pages (from-to)1320-1328
Number of pages9
JournalGenome Biology and Evolution
Volume9
Issue number5
DOIs
Publication statusPublished - 1 May 2017

Keywords

  • Molecular clocks
  • Bayesian relaxed-clock methods
  • RelTime
  • Animal evolution
  • Fossil calibrations

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