Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension

Denielli da Silva Gonçalves Bos; Chris Happé; Ingrid Schalij; Wioletta Pijacka; Julian F.R. Paton; Christophe Guignabert; Ly Tu; Raphaël Thuillet; Harm-Jan Bogaard; Albert C. van Rossum; Anton Vonk-Noordegraaf; Frances S. de Man; M. Louis Handoko

doi:10.1016/j.jacbts.2016.09.007

Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension

Denielli da Silva Gonçalves Bos, Chris Happé, Ingrid Schalij, Wioletta Pijacka, Julian F.R. Paton, Christophe Guignabert, Ly Tu, Raphaël Thuillet, Harm-Jan Bogaard, Albert C. van Rossum, Anton Vonk-Noordegraaf, Frances S. de Man, M. Louis Handoko

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

Summary Neurohormonal overactivation plays an important role in pulmonary hypertension (PH). In this context, renal denervation, which aims to inhibit the neurohormonal systems, may be a promising adjunct therapy in PH. In this proof-of-concept study, we have demonstrated in 2 experimental models of PH that renal denervation delayed disease progression, reduced pulmonary vascular remodeling, lowered right ventricular afterload, and decreased right ventricular diastolic stiffness, most likely by suppression of the renin-angiotensin-aldosterone system.

Original language	English
Pages (from-to)	22–35
Number of pages	14
Journal	JACC: Basic to Translational Science
Volume	2
Issue number	1
Early online date	1 Feb 2017
DOIs	https://doi.org/10.1016/j.jacbts.2016.09.007
Publication status	Published - Feb 2017

Keywords

pulmonary hypertension
renin angiotensin system
right ventricular failure
sympathetic nervous system

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da Silva Gonçalves Bos, D., Happé, C., Schalij, I., Pijacka, W., Paton, J. F. R., Guignabert, C., Tu, L., Thuillet, R., Bogaard, H.-J., van Rossum, A. C., Vonk-Noordegraaf, A., de Man, F. S., & Handoko, M. L. (2017). Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension. JACC: Basic to Translational Science, 2(1), 22–35. https://doi.org/10.1016/j.jacbts.2016.09.007

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title = "Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension",

abstract = "Summary Neurohormonal overactivation plays an important role in pulmonary hypertension (PH). In this context, renal denervation, which aims to inhibit the neurohormonal systems, may be a promising adjunct therapy in PH. In this proof-of-concept study, we have demonstrated in 2 experimental models of PH that renal denervation delayed disease progression, reduced pulmonary vascular remodeling, lowered right ventricular afterload, and decreased right ventricular diastolic stiffness, most likely by suppression of the renin-angiotensin-aldosterone system.",

keywords = "pulmonary hypertension, renin angiotensin system, right ventricular failure, sympathetic nervous system",

author = "{da Silva Gon{\c c}alves Bos}, Denielli and Chris Happ{\'e} and Ingrid Schalij and Wioletta Pijacka and Paton, {Julian F.R.} and Christophe Guignabert and Ly Tu and Rapha{\"e}l Thuillet and Harm-Jan Bogaard and {van Rossum}, {Albert C.} and Anton Vonk-Noordegraaf and {de Man}, {Frances S.} and Handoko, {M. Louis}",

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doi = "10.1016/j.jacbts.2016.09.007",

language = "English",

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journal = "JACC: Basic to Translational Science",

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da Silva Gonçalves Bos, D, Happé, C, Schalij, I, Pijacka, W, Paton, JFR, Guignabert, C, Tu, L, Thuillet, R, Bogaard, H-J, van Rossum, AC, Vonk-Noordegraaf, A, de Man, FS & Handoko, ML 2017, 'Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension', JACC: Basic to Translational Science, vol. 2, no. 1, pp. 22–35. https://doi.org/10.1016/j.jacbts.2016.09.007

Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension. / da Silva Gonçalves Bos, Denielli; Happé, Chris; Schalij, Ingrid et al.
In: JACC: Basic to Translational Science, Vol. 2, No. 1, 02.2017, p. 22–35.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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AU - Tu, Ly

AU - Thuillet, Raphaël

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KW - renin angiotensin system

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