Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension

Denielli da Silva Gonçalves Bos, Chris Happé, Ingrid Schalij, Wioletta Pijacka, Julian F.R. Paton, Christophe Guignabert, Ly Tu, Raphaël Thuillet, Harm-Jan Bogaard, Albert C. van Rossum, Anton Vonk-Noordegraaf, Frances S. de Man, M. Louis Handoko

Research output: Contribution to journalArticle (Academic Journal)

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Abstract

Summary Neurohormonal overactivation plays an important role in pulmonary hypertension (PH). In this context, renal denervation, which aims to inhibit the neurohormonal systems, may be a promising adjunct therapy in PH. In this proof-of-concept study, we have demonstrated in 2 experimental models of PH that renal denervation delayed disease progression, reduced pulmonary vascular remodeling, lowered right ventricular afterload, and decreased right ventricular diastolic stiffness, most likely by suppression of the renin-angiotensin-aldosterone system.
Original languageEnglish
Pages (from-to)22–35
Number of pages14
JournalJACC: Basic to Translational Science
Volume2
Issue number1
Early online date1 Feb 2017
DOIs
Publication statusPublished - Feb 2017

Keywords

  • pulmonary hypertension
  • renin angiotensin system
  • right ventricular failure
  • sympathetic nervous system

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    da Silva Gonçalves Bos, D., Happé, C., Schalij, I., Pijacka, W., Paton, J. F. R., Guignabert, C., Tu, L., Thuillet, R., Bogaard, H-J., van Rossum, A. C., Vonk-Noordegraaf, A., de Man, F. S., & Handoko, M. L. (2017). Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension. JACC: Basic to Translational Science, 2(1), 22–35. https://doi.org/10.1016/j.jacbts.2016.09.007