Renal Denervation Update From the International Sympathetic Nervous System Summit: JACC State-of-the-Art Review

Márcio G. Kiuchi, Murray D. Esler, Gregory D. Fink, John W. Osborn, Christopher T. Banek, Michael Böhm, Kate M. Denton, Gerald F. DiBona, Thomas H. Everett, Guido Grassi, Richard E. Katholi, Mark M. Knuepfer, Ulla C. Kopp, David J. Lefer, Thomas E. Lohmeier, Clive N. May, Felix Mahfoud, Julian F.R. Paton, Roland E. Schmieder, Peter R. PellegrinoYehonatan Sharabi, Markus P. Schlaich*

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

68 Citations (Scopus)
106 Downloads (Pure)


Three recent renal denervation studies in both drug-naïve and drug-treated hypertensive patients demonstrated a significant reduction of ambulatory blood pressure compared with respective sham control groups. Improved trial design, selection of relevant patient cohorts, and optimized interventional procedures have likely contributed to these positive findings. However, substantial variability in the blood pressure response to renal denervation can still be observed and remains a challenging and important problem. The International Sympathetic Nervous System Summit was convened to bring together experts in both experimental and clinical medicine to discuss the current evidence base, novel developments in our understanding of neural interplay, procedural aspects, monitoring of technical success, and others. Identification of relevant trends in the field and initiation of tailored and combined experimental and clinical research efforts will help to address remaining questions and provide much-needed evidence to guide clinical use of renal denervation for hypertension treatment and other potential indications.

Original languageEnglish
Pages (from-to)3006-3017
Number of pages27
JournalJournal of the American College of Cardiology
Issue number23
Early online date10 Jun 2019
Publication statusPublished - 18 Jun 2019


  • blood pressure
  • cardiovascular disease
  • hypertension
  • renal denervation
  • sympathetic nervous system


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