Renal tissue engineering for regenerative medicine using polymers and hydrogels

Syed mohammad daniel Syed mohamed; Gavin i. Welsh; Ipsita Roy

doi:10.1039/D3BM00255A

Renal tissue engineering for regenerative medicine using polymers and hydrogels

Syed mohammad daniel Syed mohamed, Gavin i. Welsh, Ipsita Roy^*

^*Corresponding author for this work

Bristol Medical School (THS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

11 Citations (Scopus)

Abstract

Chronic Kidney Disease (CKD) is a growing worldwide problem, leading to end-stage renal disease (ESRD). Current treatments for ESRD include haemodialysis and kidney transplantation, but both are deemed inadequate since haemodialysis does not address all other kidney functions, and there is a shortage of suitable donor organs for transplantation. Research in kidney tissue engineering has been initiated to take a regenerative medicine approach as a potential treatment alternative, either to develop effective cell therapy for reconstruction or engineer a functioning bioartificial kidney. Currently, renal tissue engineering encompasses various materials, mainly polymers and hydrogels, which have been chosen to recreate the sophisticated kidney architecture. It is essential to address the chemical and mechanical aspects of the materials to ensure they can support cell development to restore functionality and feasibility. This paper reviews the types of polymers and hydrogels that have been used in kidney tissue engineering applications, both natural and synthetic, focusing on the processing and formulation used in creating bioactive substrates and how these biomaterials affect the cell biology of the kidney cells used.

Original language	English
Pages (from-to)	5706-5726
Number of pages	21
Journal	Biomaterials Science
Volume	11
Issue number	17
Early online date	23 Jun 2023
DOIs	https://doi.org/10.1039/D3BM00255A
Publication status	E-pub ahead of print - 23 Jun 2023

Bibliographical note

Funding Information:
S. M. D. S. M. acknowledges funding by a scholarship programme, ‘Program Pelajar Cemerlang’ (Excellent Student Programme) by The Public Service Department, The Government of Malaysia. IR acknowledges funding by the EPSRC funded project (Grant no. EP/V012126/1) “SEE MORE MAKE MORE: Secondary Electron Energy Measurement Optimization for Reliable Manufacturing of Key Materials: Opportunities, Realisation & Exploitation (SM3)”. Authors also acknowledge Dr Santosh S. V. Tetali for her kind insights and inputs on kidney diseases from medical perspective for this review write-up.

Publisher Copyright:
© 2023 The Royal Society of Chemistry.

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title = "Renal tissue engineering for regenerative medicine using polymers and hydrogels",

abstract = "Chronic Kidney Disease (CKD) is a growing worldwide problem, leading to end-stage renal disease (ESRD). Current treatments for ESRD include haemodialysis and kidney transplantation, but both are deemed inadequate since haemodialysis does not address all other kidney functions, and there is a shortage of suitable donor organs for transplantation. Research in kidney tissue engineering has been initiated to take a regenerative medicine approach as a potential treatment alternative, either to develop effective cell therapy for reconstruction or engineer a functioning bioartificial kidney. Currently, renal tissue engineering encompasses various materials, mainly polymers and hydrogels, which have been chosen to recreate the sophisticated kidney architecture. It is essential to address the chemical and mechanical aspects of the materials to ensure they can support cell development to restore functionality and feasibility. This paper reviews the types of polymers and hydrogels that have been used in kidney tissue engineering applications, both natural and synthetic, focusing on the processing and formulation used in creating bioactive substrates and how these biomaterials affect the cell biology of the kidney cells used.",

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AU - Welsh, Gavin i.

AU - Roy, Ipsita

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N2 - Chronic Kidney Disease (CKD) is a growing worldwide problem, leading to end-stage renal disease (ESRD). Current treatments for ESRD include haemodialysis and kidney transplantation, but both are deemed inadequate since haemodialysis does not address all other kidney functions, and there is a shortage of suitable donor organs for transplantation. Research in kidney tissue engineering has been initiated to take a regenerative medicine approach as a potential treatment alternative, either to develop effective cell therapy for reconstruction or engineer a functioning bioartificial kidney. Currently, renal tissue engineering encompasses various materials, mainly polymers and hydrogels, which have been chosen to recreate the sophisticated kidney architecture. It is essential to address the chemical and mechanical aspects of the materials to ensure they can support cell development to restore functionality and feasibility. This paper reviews the types of polymers and hydrogels that have been used in kidney tissue engineering applications, both natural and synthetic, focusing on the processing and formulation used in creating bioactive substrates and how these biomaterials affect the cell biology of the kidney cells used.

AB - Chronic Kidney Disease (CKD) is a growing worldwide problem, leading to end-stage renal disease (ESRD). Current treatments for ESRD include haemodialysis and kidney transplantation, but both are deemed inadequate since haemodialysis does not address all other kidney functions, and there is a shortage of suitable donor organs for transplantation. Research in kidney tissue engineering has been initiated to take a regenerative medicine approach as a potential treatment alternative, either to develop effective cell therapy for reconstruction or engineer a functioning bioartificial kidney. Currently, renal tissue engineering encompasses various materials, mainly polymers and hydrogels, which have been chosen to recreate the sophisticated kidney architecture. It is essential to address the chemical and mechanical aspects of the materials to ensure they can support cell development to restore functionality and feasibility. This paper reviews the types of polymers and hydrogels that have been used in kidney tissue engineering applications, both natural and synthetic, focusing on the processing and formulation used in creating bioactive substrates and how these biomaterials affect the cell biology of the kidney cells used.

U2 - 10.1039/D3BM00255A

DO - 10.1039/D3BM00255A

M3 - Article (Academic Journal)

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JO - Biomaterials Science

JF - Biomaterials Science

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ER -

Renal tissue engineering for regenerative medicine using polymers and hydrogels

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