Abstract
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression with important roles in cancer, cardiovascular and neurological disorders. Present in the brain, they play numerous regulatory roles shaping the proteome in an orchestrated manner with other non-coding RNAs.
An independent brain-specific renin-angiotensin system (RAS) exists that is subject to miRNA remodelling. The brain RAS regulates cerebral blood flow, electrolytic balance and is involved in neurotransmitter signalling and cognitive processes. Circulating microRNAs allow interaction between systemic and local RAS in the heart and the brain. Their screening and manipulation may be valuable towards understanding pathophysiology and development of treatments for various systemic and central nervous system diseases.
An independent brain-specific renin-angiotensin system (RAS) exists that is subject to miRNA remodelling. The brain RAS regulates cerebral blood flow, electrolytic balance and is involved in neurotransmitter signalling and cognitive processes. Circulating microRNAs allow interaction between systemic and local RAS in the heart and the brain. Their screening and manipulation may be valuable towards understanding pathophysiology and development of treatments for various systemic and central nervous system diseases.
| Original language | English |
|---|---|
| Title of host publication | Renin-angiotensin system |
| Subtitle of host publication | past, present and future |
| Place of Publication | Croatia |
| Publisher | InTech |
| ISBN (Print) | 9789535150190 |
| DOIs | |
| Publication status | Published - 12 Jul 2017 |
Research Groups and Themes
- Cerebrovascular and Dementia Research Group
Keywords
- Non-coding RNAs
- MicroRNAs
- Brain renin-angiotensin system
- Cerebrovascular disease
- Circulating microRNAs
- Biomarkers
Access to Document
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Renin angiotensin system microRNAs, special focus on the brain
Submitted manuscript, 445 KB