Renin-angiotensin system microRNAs: special focus on the brain

Jose Gerardo-Aviles, Shelley Allen-Birt, Patrick Kehoe

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

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Abstract

MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression with important roles in cancer, cardiovascular and neurological disorders. Present in the brain, they play numerous regulatory roles shaping the proteome in an orchestrated manner with other non-coding RNAs.
An independent brain-specific renin-angiotensin system (RAS) exists that is subject to miRNA remodelling. The brain RAS regulates cerebral blood flow, electrolytic balance and is involved in neurotransmitter signalling and cognitive processes. Circulating microRNAs allow interaction between systemic and local RAS in the heart and the brain. Their screening and manipulation may be valuable towards understanding pathophysiology and development of treatments for various systemic and central nervous system diseases.
Original languageEnglish
Title of host publicationRenin-angiotensin system
Subtitle of host publicationpast, present and future
Place of PublicationCroatia
PublisherInTech
ISBN (Print)9789535150190
DOIs
Publication statusPublished - 12 Jul 2017

Keywords

  • Non-coding RNAs
  • MicroRNAs
  • Brain renin-angiotensin system
  • Cerebrovascular disease
  • Circulating microRNAs
  • Biomarkers

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    Gerardo-Aviles, J., Allen-Birt, S., & Kehoe, P. (2017). Renin-angiotensin system microRNAs: special focus on the brain. In Renin-angiotensin system : past, present and future InTech. https://doi.org/10.5772/67080