Reporting animal research: Explanation and Elaboration for the ARRIVE guidelines 2019

Nathalie Percie du Sert; Amrita Ahluwalia; Sabina Alam; Marc T Avey; Monya Baker; William J Browne; Alejandra Clark; Innes C Cuthill; Ulrich Dirnagl; Michael Emerson; Paul Garner; Stephen T. Holgate; David W Howells; Viki Hurst; Natasha A. Karp; Katie Lidster; Catriona J  MacCallum; Malcolm Macleod; Esther J Pearl; Ole Petersen; Frances Rawle; Penny Reynolds; Kieron  Rooney; Emily S Sena; Shai D Silberberg; Thomas Steckler; Hanno Würbel

doi:10.1101/703355

Reporting animal research: Explanation and Elaboration for the ARRIVE guidelines 2019

Nathalie Percie du Sert, Amrita Ahluwalia, Sabina Alam, Marc T Avey, Monya Baker, William J Browne, Alejandra Clark, Innes C Cuthill, Ulrich Dirnagl, Michael Emerson, Paul Garner, Stephen T. Holgate, David W Howells, Viki Hurst, Natasha A. Karp, Katie Lidster, Catriona J MacCallum, Malcolm Macleod, Esther J Pearl, Ole PetersenFrances Rawle, Penny Reynolds, Kieron Rooney, Emily S Sena, Shai D Silberberg, Thomas Steckler, Hanno Würbel

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Abstract

Improving the reproducibility of biomedical research is a major challenge. Transparent and accurate reporting are vital to this process; it allows readers to assess the reliability of the findings, and repeat or build upon the work of other researchers. The NC3Rs developed the ARRIVE guidelines in 2010 to help authors and journals identify the minimum information necessary to report in publications describing in vivo experiments.

Despite widespread endorsement by the scientific community, the impact of the ARRIVE guidelines on the transparency of reporting in animal research publications has been limited. We have revised the ARRIVE guidelines to update them and facilitate their use in practice. The revised guidelines are published alongside this paper. This Explanation and Elaboration document was developed as part of the revision. It provides further information about each of the 21 items in ARRIVE 2019, including the rationale and supporting evidence for their inclusion in the guidelines, elaboration of details to report, and examples of good reporting from the published literature.

Original language	English
Number of pages	52
Journal	bioRxiv
DOIs	https://doi.org/10.1101/703355
Publication status	Unpublished - 15 Jul 2019

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Percie du Sert, N., Ahluwalia, A., Alam, S., Avey, M. T., Baker, M., Browne, W. J., Clark, A., Cuthill, I. C., Dirnagl, U., Emerson, M., Garner, P., Holgate, S. T., Howells, D. W., Hurst, V., Karp, N. A., Lidster, K., MacCallum, C. J., Macleod, M., Pearl, E. J., ... Würbel, H. (2019). Reporting animal research: Explanation and Elaboration for the ARRIVE guidelines 2019. Unpublished. https://doi.org/10.1101/703355

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title = "Reporting animal research: Explanation and Elaboration for the ARRIVE guidelines 2019",

abstract = "Improving the reproducibility of biomedical research is a major challenge. Transparent and accurate reporting are vital to this process; it allows readers to assess the reliability of the findings, and repeat or build upon the work of other researchers. The NC3Rs developed the ARRIVE guidelines in 2010 to help authors and journals identify the minimum information necessary to report in publications describing in vivo experiments.Despite widespread endorsement by the scientific community, the impact of the ARRIVE guidelines on the transparency of reporting in animal research publications has been limited. We have revised the ARRIVE guidelines to update them and facilitate their use in practice. The revised guidelines are published alongside this paper. This Explanation and Elaboration document was developed as part of the revision. It provides further information about each of the 21 items in ARRIVE 2019, including the rationale and supporting evidence for their inclusion in the guidelines, elaboration of details to report, and examples of good reporting from the published literature.",

author = "{Percie du Sert}, Nathalie and Amrita Ahluwalia and Sabina Alam and Avey, {Marc T} and Monya Baker and Browne, {William J} and Alejandra Clark and Cuthill, {Innes C} and Ulrich Dirnagl and Michael Emerson and Paul Garner and Holgate, {Stephen T.} and Howells, {David W} and Viki Hurst and Karp, {Natasha A.} and Katie Lidster and MacCallum, {Catriona J} and Malcolm Macleod and Pearl, {Esther J} and Ole Petersen and Frances Rawle and Penny Reynolds and Kieron Rooney and Sena, {Emily S} and Silberberg, {Shai D} and Thomas Steckler and Hanno W{\"u}rbel",

year = "2019",

month = jul,

day = "15",

doi = "10.1101/703355",

language = "English",

journal = "bioRxiv",

publisher = "Cold Spring Harbor Laboratory",

}

Percie du Sert, N, Ahluwalia, A, Alam, S, Avey, MT, Baker, M, Browne, WJ, Clark, A, Cuthill, IC, Dirnagl, U, Emerson, M, Garner, P, Holgate, ST, Howells, DW, Hurst, V, Karp, NA, Lidster, K, MacCallum, CJ, Macleod, M, Pearl, EJ, Petersen, O, Rawle, F, Reynolds, P, Rooney, K, Sena, ES, Silberberg, SD, Steckler, T & Würbel, H 2019, 'Reporting animal research: Explanation and Elaboration for the ARRIVE guidelines 2019', bioRxiv. https://doi.org/10.1101/703355

TY - JOUR

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T2 - Explanation and Elaboration for the ARRIVE guidelines 2019

AU - Percie du Sert, Nathalie

AU - Ahluwalia, Amrita

AU - Alam, Sabina

AU - Avey, Marc T

AU - Baker, Monya

AU - Browne, William J

AU - Clark, Alejandra

AU - Cuthill, Innes C

AU - Dirnagl, Ulrich

AU - Emerson, Michael

AU - Garner, Paul

AU - Holgate, Stephen T.

AU - Howells, David W

AU - Hurst, Viki

AU - Karp, Natasha A.

AU - Lidster, Katie

AU - MacCallum, Catriona J

AU - Macleod, Malcolm

AU - Pearl, Esther J

AU - Petersen, Ole

AU - Rawle, Frances

AU - Reynolds, Penny

AU - Rooney, Kieron

AU - Sena, Emily S

AU - Silberberg, Shai D

AU - Steckler, Thomas

AU - Würbel, Hanno

PY - 2019/7/15

Y1 - 2019/7/15

N2 - Improving the reproducibility of biomedical research is a major challenge. Transparent and accurate reporting are vital to this process; it allows readers to assess the reliability of the findings, and repeat or build upon the work of other researchers. The NC3Rs developed the ARRIVE guidelines in 2010 to help authors and journals identify the minimum information necessary to report in publications describing in vivo experiments.Despite widespread endorsement by the scientific community, the impact of the ARRIVE guidelines on the transparency of reporting in animal research publications has been limited. We have revised the ARRIVE guidelines to update them and facilitate their use in practice. The revised guidelines are published alongside this paper. This Explanation and Elaboration document was developed as part of the revision. It provides further information about each of the 21 items in ARRIVE 2019, including the rationale and supporting evidence for their inclusion in the guidelines, elaboration of details to report, and examples of good reporting from the published literature.

AB - Improving the reproducibility of biomedical research is a major challenge. Transparent and accurate reporting are vital to this process; it allows readers to assess the reliability of the findings, and repeat or build upon the work of other researchers. The NC3Rs developed the ARRIVE guidelines in 2010 to help authors and journals identify the minimum information necessary to report in publications describing in vivo experiments.Despite widespread endorsement by the scientific community, the impact of the ARRIVE guidelines on the transparency of reporting in animal research publications has been limited. We have revised the ARRIVE guidelines to update them and facilitate their use in practice. The revised guidelines are published alongside this paper. This Explanation and Elaboration document was developed as part of the revision. It provides further information about each of the 21 items in ARRIVE 2019, including the rationale and supporting evidence for their inclusion in the guidelines, elaboration of details to report, and examples of good reporting from the published literature.

U2 - 10.1101/703355

DO - 10.1101/703355

M3 - Article (Academic Journal)

JO - bioRxiv

JF - bioRxiv

ER -

Reporting animal research: Explanation and Elaboration for the ARRIVE guidelines 2019

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