Reporting animal research: Explanation and Elaboration for the ARRIVE guidelines 2019

Nathalie Percie du Sert, Amrita Ahluwalia, Sabina Alam, Marc T Avey, Monya Baker, William J Browne, Alejandra Clark, Innes C Cuthill, Ulrich Dirnagl, Michael Emerson, Paul Garner, Stephen T. Holgate, David W Howells, Viki Hurst, Natasha A. Karp, Katie Lidster, Catriona J MacCallum, Malcolm Macleod, Esther J Pearl, Ole PetersenFrances Rawle, Penny Reynolds, Kieron Rooney, Emily S Sena, Shai D Silberberg, Thomas Steckler, Hanno Würbel

Research output: Contribution to journalArticle (Academic Journal)

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Improving the reproducibility of biomedical research is a major challenge. Transparent and accurate reporting are vital to this process; it allows readers to assess the reliability of the findings, and repeat or build upon the work of other researchers. The NC3Rs developed the ARRIVE guidelines in 2010 to help authors and journals identify the minimum information necessary to report in publications describing in vivo experiments.

Despite widespread endorsement by the scientific community, the impact of the ARRIVE guidelines on the transparency of reporting in animal research publications has been limited. We have revised the ARRIVE guidelines to update them and facilitate their use in practice. The revised guidelines are published alongside this paper. This Explanation and Elaboration document was developed as part of the revision. It provides further information about each of the 21 items in ARRIVE 2019, including the rationale and supporting evidence for their inclusion in the guidelines, elaboration of details to report, and examples of good reporting from the published literature.
Original languageEnglish
Number of pages52
Publication statusUnpublished - 15 Jul 2019

Structured keywords

  • SoE Centre for Multilevel Modelling


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