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Research Techniques Made Simple: Using Genetic Variants for Randomization

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Research Techniques Made Simple : Using Genetic Variants for Randomization. / Budu-Aggrey, Ashley; Paternoster, Lavinia.

In: Journal of Investigative Dermatology, Vol. 139, No. 7, 01.07.2019, p. 1416-1421.e1.

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Budu-Aggrey, Ashley ; Paternoster, Lavinia. / Research Techniques Made Simple : Using Genetic Variants for Randomization. In: Journal of Investigative Dermatology. 2019 ; Vol. 139, No. 7. pp. 1416-1421.e1.

Bibtex

@article{fd93281e8fa6450594fc82ed1eeca67a,
title = "Research Techniques Made Simple: Using Genetic Variants for Randomization",
abstract = "Observational epidemiological studies have identified associations between a number of modifiable exposures and outcomes, including in dermatology, such as between smoking and psoriasis. However, it is challenging to determine if such relationships are causal, due to the potential of confounding and reverse causation. Mendelian Randomization (MR) is a statistical method which can be used to investigate the causal relationships between an exposure and outcome, by using a genetic instrument that proxies the exposure. The resulting estimate (under certain assumptions) can be interpreted as the causal estimate, free of confounding and reverse causation. In this review, we provide an overview of how to undertake an MR analysis, with examples from the dermatology literature. We also discuss the challenges and future directions of this method.",
keywords = "Epidemiology, Genetics, Inflammatory skin diseases, Statistics",
author = "Ashley Budu-Aggrey and Lavinia Paternoster",
year = "2019",
month = "7",
day = "1",
doi = "10.1016/j.jid.2019.03.1138",
language = "English",
volume = "139",
pages = "1416--1421.e1",
journal = "Journal of Investigative Dermatology",
issn = "0022-202X",
publisher = "Elsevier Inc.",
number = "7",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Research Techniques Made Simple

T2 - Using Genetic Variants for Randomization

AU - Budu-Aggrey, Ashley

AU - Paternoster, Lavinia

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Observational epidemiological studies have identified associations between a number of modifiable exposures and outcomes, including in dermatology, such as between smoking and psoriasis. However, it is challenging to determine if such relationships are causal, due to the potential of confounding and reverse causation. Mendelian Randomization (MR) is a statistical method which can be used to investigate the causal relationships between an exposure and outcome, by using a genetic instrument that proxies the exposure. The resulting estimate (under certain assumptions) can be interpreted as the causal estimate, free of confounding and reverse causation. In this review, we provide an overview of how to undertake an MR analysis, with examples from the dermatology literature. We also discuss the challenges and future directions of this method.

AB - Observational epidemiological studies have identified associations between a number of modifiable exposures and outcomes, including in dermatology, such as between smoking and psoriasis. However, it is challenging to determine if such relationships are causal, due to the potential of confounding and reverse causation. Mendelian Randomization (MR) is a statistical method which can be used to investigate the causal relationships between an exposure and outcome, by using a genetic instrument that proxies the exposure. The resulting estimate (under certain assumptions) can be interpreted as the causal estimate, free of confounding and reverse causation. In this review, we provide an overview of how to undertake an MR analysis, with examples from the dermatology literature. We also discuss the challenges and future directions of this method.

KW - Epidemiology

KW - Genetics

KW - Inflammatory skin diseases

KW - Statistics

UR - http://www.scopus.com/inward/record.url?scp=85067205552&partnerID=8YFLogxK

U2 - 10.1016/j.jid.2019.03.1138

DO - 10.1016/j.jid.2019.03.1138

M3 - Review article

C2 - 31230636

AN - SCOPUS:85067205552

VL - 139

SP - 1416-1421.e1

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

SN - 0022-202X

IS - 7

ER -