Resident Immunity in Tissue Repair and Maintenance: The Zebrafish Model Coming of Age

Raquel Rua Martins, Pam Ellis, Ryan MacDonald, Beck Richardson, Catarina Martins Henriques

Research output: Contribution to journalComment/debate (Academic Journal)peer-review

20 Citations (Scopus)
520 Downloads (Pure)


The zebrafish has emerged as an exciting vertebrate model to study different aspects of immune system development, particularly due to its transparent embryonic development, the availability of multiple fluorescent reporter lines, efficient genetic tools and live imaging capabilities. However, the study of immunity in zebrafish has largely been limited to early larval stages due to an incomplete knowledge of the full repertoire of immune cells and their specific markers, in particular, a lack of cell surface antibodies to detect and isolate such cells in living tissues. Here we focus on tissue resident or associated immunity beyond development, in the adult zebrafish. It is our view that, with our increasing knowledge and the development of improved tools and protocols, the adult zebrafish will be increasingly appreciated for offering valuable insights into the role of immunity in tissue repair and maintenance, in both health and disease throughout the lifecourse.
Original languageEnglish
Article number12
Number of pages11
JournalFrontiers in Cell and Developmental Biology
Publication statusPublished - 5 Feb 2019


  • adult zebrafish (Danio Rerio)
  • tissue resident immunity
  • tissue repair and regeneration
  • ageing
  • gut
  • retina
  • brain


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