Resistance to and synthesis of the antibiotic mupirocin

Christopher M. Thomas, Joanne Hothersall, Christine L. Willis, Thomas J. Simpson

Research output: Contribution to journalArticle (Academic Journal)

103 Citations (Scopus)

Abstract

Mupirocin, a polyketide antibiotic produced by Pseudomonas fluorescens, is used to control the carriage of methicillin-resistant Staphylococcus aureus on skin and in nasal passages as well as for various skin infections. Low-level resistance to the antibiotic arises by mutation of the mupirocin target, isoleucyl-tRNA synthetase, whereas high-level resistance is due to the presence of an isoleucyl-tRNA synthetase with many similarities to eukaryotic enzymes. Mupirocin biosynthesis is carried out by a combination of type I multifunctional polyketide synthases and tailoring enzymes encoded in a 75 kb gene cluster. Chemical synthesis has also been achieved. This knowledge should allow the synthesis of new and modified antibiotics for the future.

Original languageEnglish
Pages (from-to)281-289
Number of pages9
JournalNature Reviews Microbiology
Volume8
Issue number4
DOIs
Publication statusPublished - Apr 2010

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  • Projects

    BIOSYNTHESIS OF POLYKETIDE ANTIBIOTIC MUPIROCIN BY PSEUDOMONAS FLUORESCENS

    Simpson, T. J.

    1/12/071/05/11

    Project: Research

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