Projects per year
Abstract
MCR (mobile colistin resistance) enzymes catalyse phosphoethanolamine (PEA) addition to bacterial lipid A, threatening the “last-resort” antibiotic colistin. Molecular dynamics and density functional theory simulations indicate that monozinc MCR supports PEA transfer to the Thr285 acceptor, positioning MCR as a mono- rather than multinuclear member of the alkaline phosphatase superfamily.
Original language | English |
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Pages (from-to) | 6874-6877 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 56 |
Issue number | 50 |
Early online date | 6 May 2020 |
DOIs | |
Publication status | Published - 25 Jun 2020 |
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Dive into the research topics of 'Resistance to the “Last Resort” Antibiotic Colistin: A Single-Zinc Mechanism for Phosphointermediate Formation in MCR Enzymes'. Together they form a unique fingerprint.Projects
- 2 Finished
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Link account to CHEM RB1768 (EP/M027546/1) - Bristolbridge-Nanospears
Su, B. (Principal Investigator)
11/01/16 → 10/04/16
Project: Research
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CCP-BioSim: Biomolecular Simulation at the Life Sciences Interface
Mulholland, A. J. (Principal Investigator)
1/07/15 → 30/04/21
Project: Research
Equipment
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HPC (High Performance Computing) and HTC (High Throughput Computing) Facilities
Alam, S. R. (Manager), Williams, D. A. G. (Manager), Eccleston, P. E. (Manager) & Greene, D. (Manager)
Facility/equipment: Facility