Resistance to the “Last Resort” Antibiotic Colistin: A Single-Zinc Mechanism for Phosphointermediate Formation in MCR Enzymes

Emily Lythell, Reynier Suardiaz Del Rio, Philip Hinchliffe, Chonnikan Hanpaibool, Surawit Visitsatthawong, A. Sofia. F Oliveira, Eric J M Lang, Panida Surawatanawong, Vannajan Sanghiran Lee, Thanyada Rungrotmongkol, Natalie Fey, James Spencer*, Adrian J Mulholland*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

Abstract

MCR (mobile colistin resistance) enzymes catalyse phosphoethanolamine (PEA) addition to bacterial lipid A, threatening the “last-resort” antibiotic colistin. Molecular dynamics and density functional theory simulations indicate that monozinc MCR supports PEA transfer to the Thr285 acceptor, positioning MCR as a mono- rather than multinuclear member of the alkaline phosphatase superfamily.
Original languageEnglish
Pages (from-to) 6874-6877
Number of pages4
JournalChemical Communications
Volume50
Early online date6 May 2020
DOIs
Publication statusPublished - 25 Jun 2020

Fingerprint Dive into the research topics of 'Resistance to the “Last Resort” Antibiotic Colistin: A Single-Zinc Mechanism for Phosphointermediate Formation in MCR Enzymes'. Together they form a unique fingerprint.

  • Cite this