Resolution of the three dimensional structure of components of the glomerular filtration barrier

Kenton P Arkill; Klaus Qvortrup; Tobias Starborg; Judith M Mantell; Carlo Knupp; Charles C Michel; Steve J Harper; Andy Hj Salmon; John M Squire; Dave O Bates; Chris R Neal

doi:10.1186/1471-2369-15-24

Resolution of the three dimensional structure of components of the glomerular filtration barrier

Kenton P Arkill, Klaus Qvortrup, Tobias Starborg, Judith M Mantell, Carlo Knupp, Charles C Michel, Steve J Harper, Andy Hj Salmon, John M Squire, Dave O Bates, Chris R Neal

Research output: Contribution to journal › Article (Academic Journal)

34 Citations (Scopus)

Abstract

The human glomerulus is the primary filtration unit of the kidney, and contains the Glomerular Filtration Barrier (GFB). The GFB had been thought to comprise 3 layers - the endothelium, the basement membrane and the podocyte foot processes. However, recent studies have suggested that at least two additional layers contribute to the function of the GFB, the endothelial glycocalyx on the vascular side, and the sub-podocyte space on the urinary side. To investigate the structure of these additional layers is difficult as it requires three-dimensional reconstruction of delicate sub-microscopic (

Original language	English
Pages (from-to)	24
Journal	BMC Nephrology
Volume	15
Issue number	1
DOIs	https://doi.org/10.1186/1471-2369-15-24
Publication status	Published - 1 Feb 2014

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10.1186/1471-2369-15-24

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Projects

2 Finished

The endothelial surface layer in diabetic microangiopathy

Salmon, A. H. J.

31/12/09 → 31/12/14

Project: Research

REGULATION OF GLOMERULAR FUNCTION BY VEGF

Bates, D. O.

1/03/07 → 1/03/10

Project: Research

Cite this

Arkill, K. P., Qvortrup, K., Starborg, T., Mantell, J. M., Knupp, C., Michel, C. C., Harper, S. J., Salmon, A. H., Squire, J. M., Bates, D. O., & Neal, C. R. (2014). Resolution of the three dimensional structure of components of the glomerular filtration barrier. BMC Nephrology, 15(1), 24. https://doi.org/10.1186/1471-2369-15-24

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abstract = "The human glomerulus is the primary filtration unit of the kidney, and contains the Glomerular Filtration Barrier (GFB). The GFB had been thought to comprise 3 layers - the endothelium, the basement membrane and the podocyte foot processes. However, recent studies have suggested that at least two additional layers contribute to the function of the GFB, the endothelial glycocalyx on the vascular side, and the sub-podocyte space on the urinary side. To investigate the structure of these additional layers is difficult as it requires three-dimensional reconstruction of delicate sub-microscopic (",

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Resolution of the three dimensional structure of components of the glomerular filtration barrier. / Arkill, Kenton P; Qvortrup, Klaus; Starborg, Tobias; Mantell, Judith M; Knupp, Carlo; Michel, Charles C; Harper, Steve J; Salmon, Andy Hj; Squire, John M; Bates, Dave O; Neal, Chris R.

In: BMC Nephrology, Vol. 15, No. 1, 01.02.2014, p. 24.

Research output: Contribution to journal › Article (Academic Journal)

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AU - Starborg, Tobias

AU - Mantell, Judith M

AU - Knupp, Carlo

AU - Michel, Charles C

AU - Harper, Steve J

AU - Salmon, Andy Hj

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AU - Bates, Dave O

AU - Neal, Chris R

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AB - The human glomerulus is the primary filtration unit of the kidney, and contains the Glomerular Filtration Barrier (GFB). The GFB had been thought to comprise 3 layers - the endothelium, the basement membrane and the podocyte foot processes. However, recent studies have suggested that at least two additional layers contribute to the function of the GFB, the endothelial glycocalyx on the vascular side, and the sub-podocyte space on the urinary side. To investigate the structure of these additional layers is difficult as it requires three-dimensional reconstruction of delicate sub-microscopic (

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