Resolution of the three dimensional structure of components of the glomerular filtration barrier

Kenton P Arkill, Klaus Qvortrup, Tobias Starborg, Judith M Mantell, Carlo Knupp, Charles C Michel, Steve J Harper, Andy Hj Salmon, John M Squire, Dave O Bates, Chris R Neal

Research output: Contribution to journalArticle (Academic Journal)peer-review

41 Citations (Scopus)

Abstract

The human glomerulus is the primary filtration unit of the kidney, and contains the Glomerular Filtration Barrier (GFB). The GFB had been thought to comprise 3 layers - the endothelium, the basement membrane and the podocyte foot processes. However, recent studies have suggested that at least two additional layers contribute to the function of the GFB, the endothelial glycocalyx on the vascular side, and the sub-podocyte space on the urinary side. To investigate the structure of these additional layers is difficult as it requires three-dimensional reconstruction of delicate sub-microscopic (
Original languageEnglish
Pages (from-to)24
JournalBMC Nephrology
Volume15
Issue number1
DOIs
Publication statusPublished - 1 Feb 2014

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