Projects per year
Abstract
The human glomerulus is the primary filtration unit of the kidney, and contains the Glomerular Filtration Barrier (GFB). The GFB had been thought to comprise 3 layers - the endothelium, the basement membrane and the podocyte foot processes. However, recent studies have suggested that at least two additional layers contribute to the function of the GFB, the endothelial glycocalyx on the vascular side, and the sub-podocyte space on the urinary side. To investigate the structure of these additional layers is difficult as it requires three-dimensional reconstruction of delicate sub-microscopic (
Original language | English |
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Pages (from-to) | 24 |
Journal | BMC Nephrology |
Volume | 15 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Feb 2014 |
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Dive into the research topics of 'Resolution of the three dimensional structure of components of the glomerular filtration barrier'. Together they form a unique fingerprint.Projects
- 2 Finished
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The endothelial surface layer in diabetic microangiopathy
Salmon, A. H. J. (Principal Investigator)
31/12/09 → 31/12/14
Project: Research
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REGULATION OF GLOMERULAR FUNCTION BY VEGF
Bates, D. O. (Principal Investigator)
1/03/07 → 1/03/10
Project: Research