Respiratory rhythm generation during gasping depends on persistent sodium current

Julian F R Paton, Ana Paula Abdala Sheikh, Hidehiko Koizumi, Jeffrey C Smith, Walter M St-John

Research output: Contribution to journalArticle (Academic Journal)peer-review

176 Citations (Scopus)


In severe hypoxia, homeostatic mechanisms maintain function of the brainstem respiratory network. We hypothesized that hypoxia involves a transition from neuronal mechanisms of normal breathing (eupnea) to a rudimentary pattern of inspiratory movements (gasping). We provide evidence for hypoxia-driven transformation within the central respiratory oscillator, in which gasping relies on persistent sodium current, whereas eupnea does not depend on this cellular mechanism.
Original languageEnglish
Pages (from-to)311-3
Number of pages3
JournalNature Neuroscience
Issue number3
Publication statusPublished - Mar 2006


  • Inhalation
  • Animals
  • Action Potentials
  • Neural Inhibition
  • Nerve Net
  • Sodium Channels
  • Anoxia
  • Rats
  • Animals, Newborn
  • Biological Clocks
  • Brain Stem
  • Periodicity
  • Sodium Channel Blockers
  • Synaptic Transmission
  • Respiratory Center


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