Respiratory rhythm generation during gasping depends on persistent sodium current

Julian F R Paton; Ana Paula Abdala Sheikh; Hidehiko Koizumi; Jeffrey C Smith; Walter M St-John

doi:10.1038/nn1650

Respiratory rhythm generation during gasping depends on persistent sodium current

Julian F R Paton, Ana Paula Abdala Sheikh, Hidehiko Koizumi, Jeffrey C Smith, Walter M St-John

Research output: Contribution to journal › Article (Academic Journal) › peer-review

181 Citations (Scopus)

Abstract

In severe hypoxia, homeostatic mechanisms maintain function of the brainstem respiratory network. We hypothesized that hypoxia involves a transition from neuronal mechanisms of normal breathing (eupnea) to a rudimentary pattern of inspiratory movements (gasping). We provide evidence for hypoxia-driven transformation within the central respiratory oscillator, in which gasping relies on persistent sodium current, whereas eupnea does not depend on this cellular mechanism.

Original language	English
Pages (from-to)	311-3
Number of pages	3
Journal	Nature Neuroscience
Volume	9
Issue number	3
DOIs	https://doi.org/10.1038/nn1650
Publication status	Published - Mar 2006

Keywords

Inhalation
Animals
Action Potentials
Neural Inhibition
Nerve Net
Sodium Channels
Anoxia
Rats
Animals, Newborn
Biological Clocks
Brain Stem
Periodicity
Sodium Channel Blockers
Synaptic Transmission
Respiratory Center

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@article{a44565cbde504ff0ade408192dbabd98,

title = "Respiratory rhythm generation during gasping depends on persistent sodium current",

abstract = "In severe hypoxia, homeostatic mechanisms maintain function of the brainstem respiratory network. We hypothesized that hypoxia involves a transition from neuronal mechanisms of normal breathing (eupnea) to a rudimentary pattern of inspiratory movements (gasping). We provide evidence for hypoxia-driven transformation within the central respiratory oscillator, in which gasping relies on persistent sodium current, whereas eupnea does not depend on this cellular mechanism.",

keywords = "Inhalation, Animals, Action Potentials, Neural Inhibition, Nerve Net, Sodium Channels, Anoxia, Rats, Animals, Newborn, Biological Clocks, Brain Stem, Periodicity, Sodium Channel Blockers, Synaptic Transmission, Respiratory Center",

author = "Paton, \{Julian F R\} and \{Abdala Sheikh\}, \{Ana Paula\} and Hidehiko Koizumi and Smith, \{Jeffrey C\} and St-John, \{Walter M\}",

year = "2006",

month = mar,

doi = "10.1038/nn1650",

language = "English",

volume = "9",

pages = "311--3",

journal = "Nature Neuroscience",

issn = "1097-6256",

publisher = "Nature Research",

number = "3",

}

TY - JOUR

T1 - Respiratory rhythm generation during gasping depends on persistent sodium current

AU - Paton, Julian F R

AU - Abdala Sheikh, Ana Paula

AU - Koizumi, Hidehiko

AU - Smith, Jeffrey C

AU - St-John, Walter M

PY - 2006/3

Y1 - 2006/3

N2 - In severe hypoxia, homeostatic mechanisms maintain function of the brainstem respiratory network. We hypothesized that hypoxia involves a transition from neuronal mechanisms of normal breathing (eupnea) to a rudimentary pattern of inspiratory movements (gasping). We provide evidence for hypoxia-driven transformation within the central respiratory oscillator, in which gasping relies on persistent sodium current, whereas eupnea does not depend on this cellular mechanism.

AB - In severe hypoxia, homeostatic mechanisms maintain function of the brainstem respiratory network. We hypothesized that hypoxia involves a transition from neuronal mechanisms of normal breathing (eupnea) to a rudimentary pattern of inspiratory movements (gasping). We provide evidence for hypoxia-driven transformation within the central respiratory oscillator, in which gasping relies on persistent sodium current, whereas eupnea does not depend on this cellular mechanism.

KW - Inhalation

KW - Animals

KW - Action Potentials

KW - Neural Inhibition

KW - Nerve Net

KW - Sodium Channels

KW - Anoxia

KW - Rats

KW - Animals, Newborn

KW - Biological Clocks

KW - Brain Stem

KW - Periodicity

KW - Sodium Channel Blockers

KW - Synaptic Transmission

KW - Respiratory Center

U2 - 10.1038/nn1650

DO - 10.1038/nn1650

M3 - Article (Academic Journal)

C2 - 16474390

SN - 1097-6256

VL - 9

SP - 311

EP - 313

JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 3

ER -

Respiratory rhythm generation during gasping depends on persistent sodium current

Abstract

Keywords

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