Response to There is little evidence that the endothelial glycocalyx has a specific role in glomerular permeability of albumin

We write in response to the letter entitled “There is little evidence that the endothelial glycocalyx has a specific role in glomerular permeability of albumin,”1 in reference to our original publication.2 The letter title is very misleading. It represents only the opinion of this author and is diametrically opposed to the data presented in our paper and an accumulating body of evidence including in vivo multiphoton measurements.3 This author’s claims are not supported by experimental observations and we and others have addressed them extensively including in a response4 to a previous similar letter. It is curious that the major focus of the letter seems to be on charge selectivity when charge is not mentioned in our paper.