Restenosis treatments using nanoparticle-based drug delivery systems

Zi Gu, Barbara Rolfe, Anita C Thomas, Zhi-Ping Xu

Research output: Contribution to journalArticle (Academic Journal)

10 Citations (Scopus)

Abstract

Restenosis, the re-narrowing of a blood vessel after removal of atherosclerotic plaque, is a major limitation of surgical treatments for atherosclerosis. Various attempts to prevent or treat restenosis by pharmacological or mechanical approaches have had limited success in clinical trials. Hence, there is wide interest in developing new strategies to prevent or treat restenosis. This review discusses ‘a new-generation therapy’ that uses functional nanoparticles to effectively deliver active drug molecules. The potential platforms for nanoparticle-based solutions to restenosis include organic (e.g. polymers, liposomes, and proteins) and inorganic nanoparticles (e.g. layered double hydroxides, titanium oxide nanotubes, and magnetic nanoparticles,). Many in vitro and in vivo studies based on these platforms demonstrate the feasibility and potential of using nanoparticle drug delivery systems for preventing or treating restenosis, but as yet few have reached clinical trials. It is suggested that using inorganic nanoparticles to target deliver multi-functional drugs will be a promising approach to preventing or treating restenosis.
Original languageEnglish
Article number10.1016/j.coph.2012.01.002
Pages (from-to)6330-6339
Number of pages10
JournalCurrent Pharmaceutical Design
Volume19
Issue number35
Publication statusPublished - Oct 2013

Keywords

  • restenosis
  • nanoparticles
  • drug delivery
  • layered double hyrdoxide

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    Gu, Z., Rolfe, B., Thomas, A. C., & Xu, Z-P. (2013). Restenosis treatments using nanoparticle-based drug delivery systems. Current Pharmaceutical Design, 19(35), 6330-6339. [10.1016/j.coph.2012.01.002].