Resting state predicts neural activity during reward-guided decision making: An fMRI study on Balloon Analogue Risk Task

Claudio Gentili; Elisa Di Rosa; Ioana Podina; Raluca Popita; Bogdan Voinescu; Daniel David

doi:10.1016/j.bbr.2021.113616

Resting state predicts neural activity during reward-guided decision making: An fMRI study on Balloon Analogue Risk Task

Claudio Gentili, Elisa Di Rosa^*, Ioana Podina, Raluca Popita, Bogdan Voinescu, Daniel David

^*Corresponding author for this work

Bristol Medical School

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Abstract

In our previous work [8], we have shown that resting state (RS) functional connectivity metrics are significantly related with behavioural performance at Balloon Analogue Risk Task (BART). In the present study we investigated the hypothesis of an association between RS metrics and neural activity evoked by BART execution. A group-level whole-brain regression was run to assess whether RS metrics predict brain activation during the BART, in a sample of 35 young healthy adults (mean age 23 ± 2 years, 25 F). Results complete the previous findings showing that RS is also significantly associated with the neural activity during BART execution. Specifically, ALFF is positively associated with the activity of both the right inferior parietal lobule and the left caudate. These new results are coherent with previous evidence indicating RS abnormalities in clinical conditions characterised by symptoms of impulse control disorders, and further suggest that RS might be a stable predictor of both behavioural indices and neural correlates of impulsivity and of reward-guided decision-making.

Original language	English
Article number	113616
Number of pages	3
Journal	Behavioural Brain Research
Volume	417
Early online date	2 Oct 2021
DOIs	https://doi.org/10.1016/j.bbr.2021.113616
Publication status	Published - 24 Jan 2022

Bibliographical note

Funding Information:
This work was carried out within the scope of the project "use-inspired basic research", for which the Department of General Psychology of the University of Padova has been recognised as "Dipartimento di Eccellenza" by the Ministry of University and Research. EDR was funded by the Marie-Skłodowska-Curie Global Fellowship MOTIVAGEING , GA# 749084 (Horizon 2020).

Publisher Copyright:
© 2021 Elsevier B.V.

Keywords

Impulsivity
Resting state
BARTVBART

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title = "Resting state predicts neural activity during reward-guided decision making: An fMRI study on Balloon Analogue Risk Task",

abstract = "In our previous work [8], we have shown that resting state (RS) functional connectivity metrics are significantly related with behavioural performance at Balloon Analogue Risk Task (BART). In the present study we investigated the hypothesis of an association between RS metrics and neural activity evoked by BART execution. A group-level whole-brain regression was run to assess whether RS metrics predict brain activation during the BART, in a sample of 35 young healthy adults (mean age 23 ± 2 years, 25 F). Results complete the previous findings showing that RS is also significantly associated with the neural activity during BART execution. Specifically, ALFF is positively associated with the activity of both the right inferior parietal lobule and the left caudate. These new results are coherent with previous evidence indicating RS abnormalities in clinical conditions characterised by symptoms of impulse control disorders, and further suggest that RS might be a stable predictor of both behavioural indices and neural correlates of impulsivity and of reward-guided decision-making.",

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author = "Claudio Gentili and {Di Rosa}, Elisa and Ioana Podina and Raluca Popita and Bogdan Voinescu and Daniel David",

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TY - JOUR

T1 - Resting state predicts neural activity during reward-guided decision making

T2 - An fMRI study on Balloon Analogue Risk Task

AU - Gentili, Claudio

AU - Di Rosa, Elisa

AU - Podina, Ioana

AU - Popita, Raluca

AU - Voinescu, Bogdan

AU - David, Daniel

N1 - Funding Information: This work was carried out within the scope of the project "use-inspired basic research", for which the Department of General Psychology of the University of Padova has been recognised as "Dipartimento di Eccellenza" by the Ministry of University and Research. EDR was funded by the Marie-Skłodowska-Curie Global Fellowship MOTIVAGEING , GA# 749084 (Horizon 2020). Publisher Copyright: © 2021 Elsevier B.V.

PY - 2022/1/24

Y1 - 2022/1/24

N2 - In our previous work [8], we have shown that resting state (RS) functional connectivity metrics are significantly related with behavioural performance at Balloon Analogue Risk Task (BART). In the present study we investigated the hypothesis of an association between RS metrics and neural activity evoked by BART execution. A group-level whole-brain regression was run to assess whether RS metrics predict brain activation during the BART, in a sample of 35 young healthy adults (mean age 23 ± 2 years, 25 F). Results complete the previous findings showing that RS is also significantly associated with the neural activity during BART execution. Specifically, ALFF is positively associated with the activity of both the right inferior parietal lobule and the left caudate. These new results are coherent with previous evidence indicating RS abnormalities in clinical conditions characterised by symptoms of impulse control disorders, and further suggest that RS might be a stable predictor of both behavioural indices and neural correlates of impulsivity and of reward-guided decision-making.

AB - In our previous work [8], we have shown that resting state (RS) functional connectivity metrics are significantly related with behavioural performance at Balloon Analogue Risk Task (BART). In the present study we investigated the hypothesis of an association between RS metrics and neural activity evoked by BART execution. A group-level whole-brain regression was run to assess whether RS metrics predict brain activation during the BART, in a sample of 35 young healthy adults (mean age 23 ± 2 years, 25 F). Results complete the previous findings showing that RS is also significantly associated with the neural activity during BART execution. Specifically, ALFF is positively associated with the activity of both the right inferior parietal lobule and the left caudate. These new results are coherent with previous evidence indicating RS abnormalities in clinical conditions characterised by symptoms of impulse control disorders, and further suggest that RS might be a stable predictor of both behavioural indices and neural correlates of impulsivity and of reward-guided decision-making.

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KW - Resting state

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DO - 10.1016/j.bbr.2021.113616

M3 - Article (Academic Journal)

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SN - 0166-4328

VL - 417

JO - Behavioural Brain Research

JF - Behavioural Brain Research

M1 - 113616

ER -

Resting state predicts neural activity during reward-guided decision making: An fMRI study on Balloon Analogue Risk Task

Abstract

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