Resurrecting the Dead (Molecules)

Jan Zaucha; Jonathan Heddle

doi:10.1016/j.csbj.2017.05.002

Resurrecting the Dead (Molecules)

Jan Zaucha, Jonathan Heddle

Research output: Contribution to journal › Article (Academic Journal) › peer-review

4 Citations (Scopus)

259 Downloads (Pure)

Abstract

Biological molecules, like organisms themselves, are subject to genetic drift and may even become “extinct”. Molecules that are no longer extant in living systems are of high interest for several reasons including insight into how existing life forms evolved and the possibility that they may have new and useful properties no longer available in currently functioning molecules. Predicting the sequence/structure of such molecules and synthesizing them so that their properties can be tested is the basis of “molecular resurrection” and may lead not only to a deeper understanding of evolution, but to production of artificial proteins with novel properties and even to insight into how life itself began.

Original language	English
Pages (from-to)	351-358
Number of pages	8
Journal	Computational and Structural Biotechnology Journal
Volume	15
Early online date	30 May 2017
DOIs	https://doi.org/10.1016/j.csbj.2017.05.002
Publication status	Published - 2017

Access to Document

10.1016/j.csbj.2017.05.002

Full-text PDF (final published version)
This is the final published version of the article (version of record). It first appeared online via Elsevier at https://doi.org/10.1016/j.csbj.2017.05.002 . Please refer to any applicable terms of use of the publisher.
Final published version, 863 KBLicence: CC BY

Handle.net

Persistent link

Cite this

@article{89f79291a69240218a53308347653ad3,

title = "Resurrecting the Dead (Molecules)",

abstract = "Biological molecules, like organisms themselves, are subject to genetic drift and may even become “extinct”. Molecules that are no longer extant in living systems are of high interest for several reasons including insight into how existing life forms evolved and the possibility that they may have new and useful properties no longer available in currently functioning molecules. Predicting the sequence/structure of such molecules and synthesizing them so that their properties can be tested is the basis of “molecular resurrection” and may lead not only to a deeper understanding of evolution, but to production of artificial proteins with novel properties and even to insight into how life itself began.",

author = "Jan Zaucha and Jonathan Heddle",

year = "2017",

doi = "10.1016/j.csbj.2017.05.002",

language = "English",

volume = "15",

pages = "351--358",

journal = "Computational and Structural Biotechnology Journal",

issn = "2001-0370",

publisher = "Research Network of Computational and Structural Biotechnology",

}

TY - JOUR

T1 - Resurrecting the Dead (Molecules)

AU - Zaucha, Jan

AU - Heddle, Jonathan

PY - 2017

Y1 - 2017

N2 - Biological molecules, like organisms themselves, are subject to genetic drift and may even become “extinct”. Molecules that are no longer extant in living systems are of high interest for several reasons including insight into how existing life forms evolved and the possibility that they may have new and useful properties no longer available in currently functioning molecules. Predicting the sequence/structure of such molecules and synthesizing them so that their properties can be tested is the basis of “molecular resurrection” and may lead not only to a deeper understanding of evolution, but to production of artificial proteins with novel properties and even to insight into how life itself began.

AB - Biological molecules, like organisms themselves, are subject to genetic drift and may even become “extinct”. Molecules that are no longer extant in living systems are of high interest for several reasons including insight into how existing life forms evolved and the possibility that they may have new and useful properties no longer available in currently functioning molecules. Predicting the sequence/structure of such molecules and synthesizing them so that their properties can be tested is the basis of “molecular resurrection” and may lead not only to a deeper understanding of evolution, but to production of artificial proteins with novel properties and even to insight into how life itself began.

U2 - 10.1016/j.csbj.2017.05.002

DO - 10.1016/j.csbj.2017.05.002

M3 - Article (Academic Journal)

C2 - 28652896

VL - 15

SP - 351

EP - 358

JO - Computational and Structural Biotechnology Journal

JF - Computational and Structural Biotechnology Journal

SN - 2001-0370

ER -

Resurrecting the Dead (Molecules)

Abstract

Access to Document

Handle.net

Fingerprint

Cite this