Retromer: A Master Conductor of Endosome Sorting

Christopher Burd*, Peter J. Cullen

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

235 Citations (Scopus)

Abstract

The endosomal network comprises an interconnected network of membranous compartments whose primary function is to receive, dissociate, and sort cargo that originates from the plasma membrane and the biosynthetic pathway. A major challenge in cell biology is to achieve a thorough molecular description of how this network operates, and in so doing, how defects contribute to the etiology and pathology of human disease. We discuss the increasing body of evidence that implicates an ancient evolutionary conserved complex, termed "retromer," as a master conductor in the complex orchestration of multiple cargo-sorting events within the endosomal network.

Original languageEnglish
Article number016774
Number of pages13
JournalCold Spring Harbor Perspectives in Biology
Volume6
Issue number2
DOIs
Publication statusPublished - Feb 2014

Keywords

  • TRANS-GOLGI NETWORK
  • MANNOSE 6-PHOSPHATE RECEPTORS
  • RETROGRADE TRANSPORT
  • WASH COMPLEX
  • RAB GTPASE
  • ALZHEIMERS-DISEASE
  • MAMMALIAN RETROMER
  • COAT COMPLEX
  • MEMBRANE RECRUITMENT
  • PROTEIN TRAFFICKING

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