Retromer Controls Planar Polarity Protein Levels and Asymmetric Localization at Intercellular Junctions

Helen Strutt; Paul F. Langton; Neil Pearson; Kirsty J. McMillan; David Strutt; Peter J. Cullen

doi:10.1016/j.cub.2018.12.027

Retromer Controls Planar Polarity Protein Levels and Asymmetric Localization at Intercellular Junctions

Helen Strutt, Paul F. Langton, Neil Pearson, Kirsty J. McMillan, David Strutt^*, Peter J. Cullen

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

Planar cell polarity—the organization of cells within a two-dimensional plane—is an important feature in tissue organization. Strutt et al. show that, in the Drosophila wing, endosomal recycling through retromer and its cargo adaptor Snx27 mediates the cell-surface localization of two key planar polarity proteins, Flamingo and Strabismus.

Original language	English
Pages (from-to)	484-491.e6
Number of pages	14
Journal	Current Biology
Volume	29
Issue number	3
Early online date	17 Jan 2019
DOIs	https://doi.org/10.1016/j.cub.2018.12.027
Publication status	Published - 4 Feb 2019

Keywords

Drosophila
endosome recycling
Flamingo
PCP
planar cell polarity
retromer
sorting nexin 27
Strabismus
WASH

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10.1016/j.cub.2018.12.027

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This is the final published version of the article (version of record). It first appeared online via Elsevier at https://www.cell.com/current-biology/fulltext/S0960-9822(18)31661-0#secsectitle0015. Please refer to any applicable terms of use of the publisher.
Final published version, 4.22 MBLicence: CC BY-NC-ND

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title = "Retromer Controls Planar Polarity Protein Levels and Asymmetric Localization at Intercellular Junctions",

abstract = "Planar cell polarity—the organization of cells within a two-dimensional plane—is an important feature in tissue organization. Strutt et al. show that, in the Drosophila wing, endosomal recycling through retromer and its cargo adaptor Snx27 mediates the cell-surface localization of two key planar polarity proteins, Flamingo and Strabismus.",

keywords = "Drosophila, endosome recycling, Flamingo, PCP, planar cell polarity, retromer, sorting nexin 27, Strabismus, WASH",

author = "Helen Strutt and Langton, {Paul F.} and Neil Pearson and McMillan, {Kirsty J.} and David Strutt and Cullen, {Peter J.}",

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AU - Strutt, Helen

AU - Langton, Paul F.

AU - Pearson, Neil

AU - McMillan, Kirsty J.

AU - Strutt, David

AU - Cullen, Peter J.

PY - 2019/2/4

Y1 - 2019/2/4

N2 - Planar cell polarity—the organization of cells within a two-dimensional plane—is an important feature in tissue organization. Strutt et al. show that, in the Drosophila wing, endosomal recycling through retromer and its cargo adaptor Snx27 mediates the cell-surface localization of two key planar polarity proteins, Flamingo and Strabismus.

AB - Planar cell polarity—the organization of cells within a two-dimensional plane—is an important feature in tissue organization. Strutt et al. show that, in the Drosophila wing, endosomal recycling through retromer and its cargo adaptor Snx27 mediates the cell-surface localization of two key planar polarity proteins, Flamingo and Strabismus.

KW - Drosophila

KW - endosome recycling

KW - Flamingo

KW - PCP

KW - planar cell polarity

KW - retromer

KW - sorting nexin 27

KW - Strabismus

KW - WASH

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U2 - 10.1016/j.cub.2018.12.027

DO - 10.1016/j.cub.2018.12.027

M3 - Article (Academic Journal)

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AN - SCOPUS:85060735569

SN - 0960-9822

VL - 29

SP - 484-491.e6

JO - Current Biology

JF - Current Biology

IS - 3

ER -

Retromer Controls Planar Polarity Protein Levels and Asymmetric Localization at Intercellular Junctions

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Defining the role of retromer-like in endosomal cargo sorting in health and disease

Professor Pete J Cullen

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Retromer Controls Planar Polarity Protein Levels and Asymmetric Localization at Intercellular Junctions

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