Retromer Controls Planar Polarity Protein Levels and Asymmetric Localization at Intercellular Junctions

Helen Strutt, Paul F. Langton, Neil Pearson, Kirsty J. McMillan, David Strutt*, Peter J. Cullen

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

3 Citations (Scopus)
212 Downloads (Pure)

Abstract

Planar cell polarity—the organization of cells within a two-dimensional plane—is an important feature in tissue organization. Strutt et al. show that, in the Drosophila wing, endosomal recycling through retromer and its cargo adaptor Snx27 mediates the cell-surface localization of two key planar polarity proteins, Flamingo and Strabismus.

Original languageEnglish
Pages (from-to)484-491.e6
Number of pages14
JournalCurrent Biology
Volume29
Issue number3
Early online date17 Jan 2019
DOIs
Publication statusPublished - 4 Feb 2019

Keywords

  • Drosophila
  • endosome recycling
  • Flamingo
  • PCP
  • planar cell polarity
  • retromer
  • sorting nexin 27
  • Strabismus
  • WASH

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