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Retromer Controls Planar Polarity Protein Levels and Asymmetric Localization at Intercellular Junctions

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)484-491.e6
Number of pages14
JournalCurrent Biology
Issue number3
Early online date17 Jan 2019
DateAccepted/In press - 14 Dec 2018
DateE-pub ahead of print - 17 Jan 2019
DatePublished (current) - 4 Feb 2019


Planar cell polarity—the organization of cells within a two-dimensional plane—is an important feature in tissue organization. Strutt et al. show that, in the Drosophila wing, endosomal recycling through retromer and its cargo adaptor Snx27 mediates the cell-surface localization of two key planar polarity proteins, Flamingo and Strabismus.

    Research areas

  • Drosophila, endosome recycling, Flamingo, PCP, planar cell polarity, retromer, sorting nexin 27, Strabismus, WASH

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