Revealing the effect of CETP inhibition in cardiovascular disease

Michael Holmes, George Davey Smith

Research output: Contribution to journalEditorial (Academic Journal)

17 Citations (Scopus)
154 Downloads (Pure)


Initial randomized trials of cholesteryl ester transfer protein (CETP) inhibitors were terminated early owing to adverse effects or futility. The REVEAL trial now shows the benefit of CETP inhibition in coronary heart disease. Despite raising HDL-cholesterol levels, the cardiovascular effect of CETP inhibitors is probably due to lowering of non-HDL-cholesterol levels.
Original languageEnglish
Pages (from-to)635–636
Number of pages2
JournalNature Reviews Cardiology
Issue number11
Early online date5 Oct 2017
Publication statusPublished - Nov 2017


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  • MRC UoB UNITE Unit - Programme 1

    Davey Smith, G.


    Project: Research

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