Rho GTPase signalling in cell migration

Research output: Contribution to journalReview article (Academic Journal)peer-review

371 Citations (Scopus)

Abstract

Cells migrate in multiple different ways depending on their environment, which includes the extracellular matrix composition, interactions with other cells, and chemical stimuli. For all types of cell migration, Rho GTPases play a central role, although the relative contribution of each Rho GTPase depends on the environment and cell type. Here, I review recent advances in our understanding of how Rho GTPases contribute to different types of migration, comparing lamellipodium-driven versus bleb-driven migration modes. I also describe how cells migrate across the endothelium. In addition to Rho, Rac and Cdc42, which are well known to regulate migration, I discuss the roles of other less-well characterized members of the Rho family.

Original languageEnglish
Pages (from-to)103-12
Number of pages10
JournalCurrent Opinion in Cell Biology
Volume36
DOIs
Publication statusPublished - Oct 2015

Keywords

  • Actins
  • Animals
  • Cell Communication
  • Cell Movement
  • Humans
  • Signal Transduction
  • rho GTP-Binding Proteins
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review

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