Rho GTPases: Regulation and roles in cancer cell biology

Raquel B Haga, Anne J Ridley

Research output: Contribution to journalReview article (Academic Journal)peer-review

Abstract

Rho GTPases are well known for their roles in regulating cell migration, and also contribute to a variety of other cellular responses. They are subdivided into 2 groups: typical and atypical. The typical Rho family members, including RhoA, Rac1 and Cdc42, cycle between an active GTP-bound and inactive GDP-bound conformation, and are regulated by GEFs, GAPs and GDIs, whereas atypical Rho family members have amino acid substitutions that alter their ability to interact with GTP/GDP and hence are regulated by different mechanisms. Both typical and atypical Rho GTPases contribute to cancer progression. In a few cancers, RhoA or Rac1 are mutated, but in most cancers expression levels and/or activity of Rho GTPases is altered. Rho GTPase signaling could therefore be therapeutically targeted in cancer treatment.

Original languageEnglish
Pages (from-to)207-221
Number of pages15
JournalSmall GTPases
Volume7
Issue number4
Early online date14 Sep 2016
DOIs
Publication statusPublished - 26 Sep 2016

Keywords

  • Amino Acid Substitution
  • Animals
  • Cell Movement
  • Disease Progression
  • Humans
  • Neoplasms
  • Signal Transduction
  • rho GTP-Binding Proteins
  • Journal Article
  • Review

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