Rhodacyclopentanones as Linchpins for the Atom Economical Assembly of Diverse Polyheterocycles

Gang Wei Wang, Olivia Boyd, Tom A. Young, Sophie M. Bertrand, John F. Bower*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

Abstract

We outline a conceptual blueprint that provides direct and atom economical access to a wide range of complex polyheterocycles. Our method capitalizes on the ambiphilic reactivity of rhodacyclopentanones that arise upon exposure of cyclopropanes to Rh(I) catalysts and CO. Using this approach, a wide array of polycyclizations are achieved, including variants that involve powerful dearomatizations and medium ring formations.

Original languageEnglish
Pages (from-to)1740-1745
Number of pages6
JournalJournal of the American Chemical Society
Volume142
Issue number4
Early online date21 Jan 2020
DOIs
Publication statusPublished - 29 Jan 2020

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