Rhodacyclopentanones as Linchpins for the Atom Economical Assembly of Diverse Polyheterocycles

Gang Wei Wang; Olivia Boyd; Tom A. Young; Sophie M. Bertrand; John F. Bower

doi:10.1021/jacs.9b12421

Rhodacyclopentanones as Linchpins for the Atom Economical Assembly of Diverse Polyheterocycles

Gang Wei Wang, Olivia Boyd, Tom A. Young, Sophie M. Bertrand, John F. Bower^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal)

Abstract

We outline a conceptual blueprint that provides direct and atom economical access to a wide range of complex polyheterocycles. Our method capitalizes on the ambiphilic reactivity of rhodacyclopentanones that arise upon exposure of cyclopropanes to Rh(I) catalysts and CO. Using this approach, a wide array of polycyclizations are achieved, including variants that involve powerful dearomatizations and medium ring formations.

Original language	English
Pages (from-to)	1740-1745
Number of pages	6
Journal	Journal of the American Chemical Society
Volume	142
Issue number	4
Early online date	21 Jan 2020
DOIs	https://doi.org/10.1021/jacs.9b12421
Publication status	Published - 29 Jan 2020

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Wang, G. W., Boyd, O., Young, T. A., Bertrand, S. M., & Bower, J. F. (2020). Rhodacyclopentanones as Linchpins for the Atom Economical Assembly of Diverse Polyheterocycles. Journal of the American Chemical Society, 142(4), 1740-1745. https://doi.org/10.1021/jacs.9b12421

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10.1021/jacs.9b12421

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