Rhodium-catalysed alkoxylation/acetalization of diazo compounds: One-step synthesis of highly functionalised quaternary carbon centres

J. Pospech, A.J.J. Lennox, M. Beller

Research output: Contribution to journalArticle (Academic Journal)

7 Citations (Scopus)

Abstract

An intermolecular tandem reaction for the rapid build-up of densely functionalised $-alkoxy-$-oxo-esters has been developed. This novel process applies the easy to handle trimethyl orthoformate as a C1-building block in the rhodium(ii)-catalysed alkoxylation/acetalization of donor-acceptor substituted diazo compounds. The concomitant C-O/C-C bond formation reaction gives products with unique quaternary carbon centers, substituted by groups of different oxidation level (ester, protected aldehyde and alkoxide).
Original languageEnglish
Pages (from-to)1359-7345
JournalChemical Communications
Volume51
Issue number77
DOIs
Publication statusPublished - 2015

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