Right internal thoracic artery or radial artery? A propensity matched comparison on the second best arterial conduit

Umberto Benedetto, Massimo Caputo, Mario Gaudino, Roberto Marsico, Cha Rajakaruna, Alan Bryan, Gianni D. Angelini

Research output: Contribution to journalArticle (Academic Journal)

13 Citations (Scopus)
253 Downloads (Pure)

Abstract

Objective(s)

We conducted a propensity score matching to determine whether the use of the right internal thoracic artery (RITA) confers a survival advantage when compared to the radial artery (RA) as second arterial conduit in coronary artery bypass grafting (CABG).

Methods

The study population included a highly selected low risk group of patients who received the RITA (n=764) or the RA (n=1990) as second arterial conduit. We obtained 764 matched pairs that were comparable for all pre-treatment variables. Time-segmented Cox regression model that stratified on the matched pairs was used to investigate the effect of treatment on late mortality.

Results

After a mean follow-up of 10.2±4.5 years (max 17.3 years), survival probabilities at 5, 10 and 15 years were 96.4±0.7% versus 95.4±0.7%, 91.0±1.1% versus 89.1±1.2% and 82.4± 1.9% versus 77.2± 2.5% in the RITA and RA groups respectively. During the first 4 years, RITA and RA were comparable in terms of mortality (HR 1.00; 95%CI 0.56-1.78; P=0.98). However, after 4 years RITA was associated with a significant reduction in late mortality (HR 0.67; 95%CI0.48-0.95; P=0.02). RITA was superior to RA when the experimental conduit was used to graft the left coronary system (HR 0.69;95%CI 0.47-0.99; P=0.04) but not the right coronary system (HR 0.98;95%CI 0.59-1.62; P=0.93)

Conclusions

In a highly selected low-risk group of patients, the use of the RITA as second arterial conduit instead of the RA, was associated with better survival when used to graft the left but not the right coronary artery.

Original languageEnglish
Pages (from-to)79–88.e4
Number of pages14
JournalJournal of Thoracic and Cardiovascular Surgery
Volume153
Issue number1
Early online date12 Sep 2016
DOIs
Publication statusPublished - Jan 2017

Structured keywords

  • Centre for Surgical Research

Keywords

  • coronary artery bypass grafting
  • multiple arterial grafting
  • propensity score matching
  • survival

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