Risk of stillbirth and neonatal death in singletons born after fresh and frozen embryo transfer: cohort study from the Committee of Nordic Assisted Reproduction Technology and Safety

Westvik-Johari Kjersti; Debbie A Lawlor; Liv Bente Romundstad; Christina  Bergh; Ulla-Britt Wennerholm; Anna-Karina Aaris Henningsen; Siri Eldevik Håberg; Alia Tiitinen; Anne Lærke  Spangmose; Anja Pinborg; Signe Opdahl

doi:10.1016/j.fertnstert.2022.10.020

Risk of stillbirth and neonatal death in singletons born after fresh and frozen embryo transfer: cohort study from the Committee of Nordic Assisted Reproduction Technology and Safety

Westvik-Johari Kjersti ^*, Debbie A Lawlor, Liv Bente Romundstad , Christina Bergh, Ulla-Britt Wennerholm, Anna-Karina Aaris Henningsen, Siri Eldevik Håberg, Alia Tiitinen, Anne Lærke Spangmose, Anja Pinborg, Signe Opdahl

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

2 Citations (Scopus)

70 Downloads (Pure)

Abstract

Objectives
To investigate whether risks of stillbirth and neonatal death differ after fresh embryo transfers (fresh-ETs) and frozen embryo transfers (frozen-ETs) compared with singletons conceived without medical assistance.

Design
A population-based cohort study.

Setting
Not applicable.

Patient(s)
Data linkage between the nationwide Medical Birth Registries in Denmark (1994–2014), Norway and Sweden (1988–2015), and national quality registries and databases on assisted reproductive technology identified a total of 4,590,853 singletons, including 78,642 conceived by fresh-ET and 18,084 by frozen-ET.

Intervention(s)
None

Main Outcome Measure(s)
Stillbirth (fetal death before and during delivery) and neonatal death (live born with death 0–27 days postpartum).

Result(s)
Overall, 17,123 (0.37%) singletons were stillborn and 7,685 (0.17%) died neonatally. Compared with singletons conceived without medical assistance, the odds of stillbirth were similar after fresh-ET and frozen-ET, whereas the odds of neonatal death were high after fresh-ET (odds ratio [OR], 1.69; 95% confidence interval [CI], 1.46–1.95) and frozen-ET (OR, 1.51; 95% CI, 1.08–2.10).

Preterm birth (
Conclusion(s)
Overall, the risk of stillbirth was similar after fresh-ET and frozen-ET compared with singletons conceived without medical assistance, whereas neonatal mortality was high, possibly mediated by the high risk of preterm birth when compared with singletons conceived without medical assistance. Our results gave no clear support for choosing one treatment over the other.

Original language	English
Journal	Fertility and Sterility
Early online date	24 Dec 2022
DOIs	https://doi.org/10.1016/j.fertnstert.2022.10.020
Publication status	E-pub ahead of print - 24 Dec 2022

Research Groups and Themes

Bristol Population Health Science Institute

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.fertnstert.2022.10.020Licence: CC BY

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This is the final published version of the article (version of record). It first appeared online via Elsevier] at https://doi.org/10.1016/j.fertnstert.2022.10.020. Please refer to any applicable terms of use of the publisher.
Final published version, 904 KBLicence: CC BY

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8073 MRC IEU - Programme 6
Lawlor, D. A. (Principal Investigator)
1/04/18 → 31/03/23
Project: Research

Cite this

Kjersti , W.-J., Lawlor, D. A., Romundstad , L. B., Bergh, C., Wennerholm, U.-B., Henningsen, A.-K. A., Håberg, S. E., Tiitinen, A., Spangmose, A. L., Pinborg, A., & Opdahl, S. (2022). Risk of stillbirth and neonatal death in singletons born after fresh and frozen embryo transfer: cohort study from the Committee of Nordic Assisted Reproduction Technology and Safety. Fertility and Sterility. Advance online publication. https://doi.org/10.1016/j.fertnstert.2022.10.020

@article{bf177d44c0e9477dbedb7cb94124f023,

title = "Risk of stillbirth and neonatal death in singletons born after fresh and frozen embryo transfer: cohort study from the Committee of Nordic Assisted Reproduction Technology and Safety",

abstract = "ObjectivesTo investigate whether risks of stillbirth and neonatal death differ after fresh embryo transfers (fresh-ETs) and frozen embryo transfers (frozen-ETs) compared with singletons conceived without medical assistance.DesignA population-based cohort study.SettingNot applicable.Patient(s)Data linkage between the nationwide Medical Birth Registries in Denmark (1994–2014), Norway and Sweden (1988–2015), and national quality registries and databases on assisted reproductive technology identified a total of 4,590,853 singletons, including 78,642 conceived by fresh-ET and 18,084 by frozen-ET.Intervention(s)NoneMain Outcome Measure(s)Stillbirth (fetal death before and during delivery) and neonatal death (live born with death 0–27 days postpartum).Result(s)Overall, 17,123 (0.37%) singletons were stillborn and 7,685 (0.17%) died neonatally. Compared with singletons conceived without medical assistance, the odds of stillbirth were similar after fresh-ET and frozen-ET, whereas the odds of neonatal death were high after fresh-ET (odds ratio [OR], 1.69; 95% confidence interval [CI], 1.46–1.95) and frozen-ET (OR, 1.51; 95% CI, 1.08–2.10).Preterm birth (Conclusion(s)Overall, the risk of stillbirth was similar after fresh-ET and frozen-ET compared with singletons conceived without medical assistance, whereas neonatal mortality was high, possibly mediated by the high risk of preterm birth when compared with singletons conceived without medical assistance. Our results gave no clear support for choosing one treatment over the other.",

author = "Westvik-Johari Kjersti and Lawlor, {Debbie A} and Romundstad, {Liv Bente} and Christina Bergh and Ulla-Britt Wennerholm and Henningsen, {Anna-Karina Aaris} and H{\aa}berg, {Siri Eldevik} and Alia Tiitinen and Spangmose, {Anne L{\ae}rke} and Anja Pinborg and Signe Opdahl",

year = "2022",

month = dec,

day = "24",

doi = "10.1016/j.fertnstert.2022.10.020",

language = "English",

journal = "Fertility and Sterility",

issn = "0015-0282",

publisher = "Elsevier Inc.",

}

Kjersti , W-J, Lawlor, DA, Romundstad , LB, Bergh, C, Wennerholm, U-B, Henningsen, A-KA, Håberg, SE, Tiitinen, A, Spangmose, AL, Pinborg, A & Opdahl, S 2022, 'Risk of stillbirth and neonatal death in singletons born after fresh and frozen embryo transfer: cohort study from the Committee of Nordic Assisted Reproduction Technology and Safety', Fertility and Sterility. https://doi.org/10.1016/j.fertnstert.2022.10.020

Risk of stillbirth and neonatal death in singletons born after fresh and frozen embryo transfer: cohort study from the Committee of Nordic Assisted Reproduction Technology and Safety. / Kjersti , Westvik-Johari; Lawlor, Debbie A; Romundstad , Liv Bente et al.
In: Fertility and Sterility, 24.12.2022.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Risk of stillbirth and neonatal death in singletons born after fresh and frozen embryo transfer

T2 - cohort study from the Committee of Nordic Assisted Reproduction Technology and Safety

AU - Kjersti , Westvik-Johari

AU - Lawlor, Debbie A

AU - Romundstad , Liv Bente

AU - Bergh, Christina

AU - Wennerholm, Ulla-Britt

AU - Henningsen, Anna-Karina Aaris

AU - Håberg, Siri Eldevik

AU - Tiitinen, Alia

AU - Spangmose, Anne Lærke

AU - Pinborg, Anja

AU - Opdahl, Signe

PY - 2022/12/24

Y1 - 2022/12/24

N2 - ObjectivesTo investigate whether risks of stillbirth and neonatal death differ after fresh embryo transfers (fresh-ETs) and frozen embryo transfers (frozen-ETs) compared with singletons conceived without medical assistance.DesignA population-based cohort study.SettingNot applicable.Patient(s)Data linkage between the nationwide Medical Birth Registries in Denmark (1994–2014), Norway and Sweden (1988–2015), and national quality registries and databases on assisted reproductive technology identified a total of 4,590,853 singletons, including 78,642 conceived by fresh-ET and 18,084 by frozen-ET.Intervention(s)NoneMain Outcome Measure(s)Stillbirth (fetal death before and during delivery) and neonatal death (live born with death 0–27 days postpartum).Result(s)Overall, 17,123 (0.37%) singletons were stillborn and 7,685 (0.17%) died neonatally. Compared with singletons conceived without medical assistance, the odds of stillbirth were similar after fresh-ET and frozen-ET, whereas the odds of neonatal death were high after fresh-ET (odds ratio [OR], 1.69; 95% confidence interval [CI], 1.46–1.95) and frozen-ET (OR, 1.51; 95% CI, 1.08–2.10).Preterm birth (Conclusion(s)Overall, the risk of stillbirth was similar after fresh-ET and frozen-ET compared with singletons conceived without medical assistance, whereas neonatal mortality was high, possibly mediated by the high risk of preterm birth when compared with singletons conceived without medical assistance. Our results gave no clear support for choosing one treatment over the other.

AB - ObjectivesTo investigate whether risks of stillbirth and neonatal death differ after fresh embryo transfers (fresh-ETs) and frozen embryo transfers (frozen-ETs) compared with singletons conceived without medical assistance.DesignA population-based cohort study.SettingNot applicable.Patient(s)Data linkage between the nationwide Medical Birth Registries in Denmark (1994–2014), Norway and Sweden (1988–2015), and national quality registries and databases on assisted reproductive technology identified a total of 4,590,853 singletons, including 78,642 conceived by fresh-ET and 18,084 by frozen-ET.Intervention(s)NoneMain Outcome Measure(s)Stillbirth (fetal death before and during delivery) and neonatal death (live born with death 0–27 days postpartum).Result(s)Overall, 17,123 (0.37%) singletons were stillborn and 7,685 (0.17%) died neonatally. Compared with singletons conceived without medical assistance, the odds of stillbirth were similar after fresh-ET and frozen-ET, whereas the odds of neonatal death were high after fresh-ET (odds ratio [OR], 1.69; 95% confidence interval [CI], 1.46–1.95) and frozen-ET (OR, 1.51; 95% CI, 1.08–2.10).Preterm birth (Conclusion(s)Overall, the risk of stillbirth was similar after fresh-ET and frozen-ET compared with singletons conceived without medical assistance, whereas neonatal mortality was high, possibly mediated by the high risk of preterm birth when compared with singletons conceived without medical assistance. Our results gave no clear support for choosing one treatment over the other.

U2 - 10.1016/j.fertnstert.2022.10.020

DO - 10.1016/j.fertnstert.2022.10.020

M3 - Article (Academic Journal)

C2 - 36567207

SN - 0015-0282

JO - Fertility and Sterility

JF - Fertility and Sterility

ER -

Risk of stillbirth and neonatal death in singletons born after fresh and frozen embryo transfer: cohort study from the Committee of Nordic Assisted Reproduction Technology and Safety

Abstract

Research Groups and Themes

UN SDGs

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Projects

8073 MRC IEU - Programme 6

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