Projects per year
Abstract
Cells have developed numerous adaptation mechanisms to external cues by controlling signaling-pathway activity, both qualitatively and quantitatively. The Wnt/β-catenin pathway is a highly conserved signaling pathway involved in many biological processes, including cell proliferation, differentiation, somatic cell reprogramming, development, and cancer. The activity of the Wnt/β-catenin pathway and the temporal dynamics of its effector β-catenin are tightly controlled by complex regulations. The latter encompass feedback loops within the pathway (e.g., a negative feedback loop involving Axin2, a β-catenin transcriptional target) and crosstalk interactions with other signaling pathways. Here, we provide a review shedding light on the coupling between Wnt/β-catenin activation levels and fluctuations across processes and cellular systems; in particular, we focus on development, in vitro pluripotency maintenance, and cancer. Possible mechanisms originating Wnt/β-catenin dynamic behaviors and consequently driving different cellular responses are also reviewed, and new avenues for future research are suggested.
Original language | English |
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Article number | 176 |
Number of pages | 22 |
Journal | Genes |
Volume | 10 |
Issue number | 2 |
Early online date | 25 Feb 2019 |
DOIs | |
Publication status | Published - Feb 2019 |
Research Groups and Themes
- BrisSynBio
- Bristol BioDesign Institute
Keywords
- Cancer
- synthetic biology
- Canonical Wnt pathway
- Signaling dynamics
- Development
- β-catenin
- Pluripotency
Fingerprint
Dive into the research topics of 'Role of β-Catenin Activation Levels and Fluctuations in Controlling Cell Fate'. Together they form a unique fingerprint.Projects
- 4 Finished
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Automatic cell fate engineering using microfluidics devices
Marucci, L. (Principal Investigator)
1/02/18 → 30/04/20
Project: Research
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Unravelling the role of beta-catenin in ground state pluripotency
Marucci, L. (Principal Investigator)
1/09/16 → 29/02/20
Project: Research
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Unravelling the role of beta-catenin in ground state pluripotency
Marucci, L. (Principal Investigator)
1/09/16 → 31/08/19
Project: Research, Parent