Role of gamma-MSH peptides in the regulation of adrenal steroidogenesis

Stephen C Harmer, Andrew B Bicknell

Research output: Contribution to journalReview article (Academic Journal)peer-review


Alpha-, beta- and gamma-melanocyte stimulating hormones (MSHs) are peptides derived from the ACTH precursor, pro-opiomelanocortin. All three peptides have been highly conserved throughout evolution but their exact biological function in mammals is still largely obscure. In recent years, there has been a surge of interest in alpha-MSH and its role in the regulation of feeding. Gamma-MSH by contrast has been shown to be involved in the regulation of adrenal steroidogenesis and also has effects on the cardiovascular and renal systems. This review will provide an overview of the role that gamma-MSH peptides play in the regulation of adrenal steroidogenesis.

Original languageEnglish
Pages (from-to)1944-51
Number of pages8
Issue number10
Publication statusPublished - Oct 2005


  • Adrenal Cortex Hormones/biosynthesis
  • Adrenal Glands/chemistry
  • Animals
  • Humans
  • Peptides/chemistry
  • Protein Processing, Post-Translational/physiology
  • Sterol Esterase/biosynthesis
  • gamma-MSH/chemistry


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