Role of prolactin in the gonadotroph responsiveness to gonadotrophin-releasing hormone during the equine annual reproductive cycle

DJ Hodson, J Townsend, SJ Gregory, C Walters, DJ Tortonese

Research output: Contribution to journalArticle (Academic Journal)

17 Citations (Scopus)

Abstract

A combined suppressive effect of prolactin (PRL) and dopamine on the secretion of luteinising hormone (LH) at the level of the pituitary gland has been identified in sheep, a short-day breeder. However, little is known about the role of PRL in the intra-pituitary regulation of the gonadotrophic axis in long-day breeders. Here, we investigated the effects of PRL on LH and follicle-stimulating hormone (FSH) secretion during the equine annual reproductive cycle. Horse pituitaries were obtained during the breeding (BS) and non-breeding (NBS) seasons. Cells were dispersed, plated to monolayer cultures and assigned to one of the following treatments: i) medium (Control); ii) rat PRL (rPRL); iii) thyrotrophin-releasing hormone (TRH); iv) bromocriptine (Br); and v) Br + rPRL. Gonadotrophin-releasing hormone (GnRH) dose-dependently stimulated LH release during the BS and NBS. During the BS, neither rPRL nor TRH affected the LH response to GnRH, but Br significantly (P
Translated title of the contributionRole of prolactin in the gonadotroph responsiveness to gonadotrophin-releasing hormone during the equine annual reproductive cycle
Original languageEnglish
Pages (from-to)509 - 517
Number of pages9
JournalJournal of Neuroendocrinology
Volume26
DOIs
Publication statusPublished - Jun 2010

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